PPM1L - protein phosphatase, Mg2+/Mn2+ dependent 1L Gene

中文名称：蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1L

种属: Homo sapiens

同用名: PP2CE; PPM1-LIKE; PP2C-epsilon

关于 PPM1L

功能概要

该基因编码的蛋白质是一种需要镁或锰的磷酸酶，参与多种信号通路。编码的蛋白质下调细胞凋亡信号调节激酶 1，这是一种在细胞受到细胞毒性应激时启动信号级联反应导致细胞凋亡的蛋白质。这种蛋白质也是一种内质网跨膜蛋白，有助于调节从内质网到高尔基体的神经酰胺转运。最后，该基因可能与肥胖有关，因为它在脂肪组织中被上调。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene is a magnesium or manganese-requiring Phosphatase that is involved in several signaling pathways. The encoded protein downregulates Apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to Apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]