2. Gene
  3. Hmga2 - high mobility group AT-hook 2 Gene

Hmga2 - high mobility group AT-hook 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: pg; Hmgic; pygmy; HMGI-C; 9430083A20Rik

基因 ID: 15364 | 基因类型: protein coding

关于 Hmga2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including animal organ development; negative regulation of astrocyte differentiation; and positive regulation of cell population proliferation. Located in nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian Cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmga2 基因产物(2)

mRNA Protein Name
NM_001347170.1 NP_001334099.1 high mobility group protein HMGI-C isoform 2
NM_010441.3 NP_034571.1 high mobility group protein HMGI-C isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables minor groove of adenine-thymine-rich DNA binding IDA
IDA: 通过直接分析推断
16109425 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14668482 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adipose tissue development IMP
IMP: 通过突变表型推断
7958830 MGI
acts upstream of or within adrenal gland development IMP
IMP: 通过突变表型推断
7958830 MGI
acts upstream of astrocyte differentiation IDA
IDA: 通过直接分析推断
18640244 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
18957199 MGI
acts upstream of or within cell proliferation in forebrain IMP
IMP: 通过突变表型推断
18957199 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: 通过突变表型推断
24661562 MGI
acts upstream of or within fat pad development IGI
IGI: 通过遗传相互作用推断
10742101 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
7651535 MGI
acts upstream of or within lung epithelium development IMP
IMP: 通过突变表型推断
24661562 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
7958830 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
24728959 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
24661562 MGI
acts upstream of or within negative regulation of astrocyte differentiation IDA
IDA: 通过直接分析推断
18640244 MGI
involved in negative regulation of cellular senescence IMP
IMP: 通过突变表型推断
23072816 MGI
acts upstream of or within pituitary gland development IMP
IMP: 通过突变表型推断
504232 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
23072816 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18957199 MGI
involved in positive regulation of cell proliferation in bone marrow IMP
IMP: 通过突变表型推断
23072816 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: 通过突变表型推断
24661562 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
7651535 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
15225648 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
5051369 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
18957199 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
24661562 MGI
involved in regulation of cell cycle process IDA
IDA: 通过直接分析推断
14645522 MGI
acts upstream of or within regulation of growth hormone secretion IMP
IMP: 通过突变表型推断
504232 MGI
acts upstream of or within regulation of peptide hormone secretion IMP
IMP: 通过突变表型推断
504232 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: 通过遗传相互作用推断
18957199 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
18957199 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
12032866 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
18957199 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
12032866 MGI
located in nuclear chromosome IDA
IDA: 通过直接分析推断
11555636 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12032866 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

high mobility group protein HMGI-C

high mobility group AT-hook protein 2

high mobility group protein I

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06231 HMGA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hmga2 NCBI NCBI:8091
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