Hspa4 - heat shock protein 4 Gene

中文名称：热休克蛋白4

种属: Mus musculus

同用名: 70kDa; APG-2; Hsp110; Hsp70RY; mKIAA4025

关于 Hspa4

功能概要

预测该基因编码的蛋白编码的蛋白可启动 RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性。预计参与多个过程，包括分子伴侣介导的蛋白质复合物组装；大分子代谢过程的负调控；和蛋白质插入线粒体外膜。预计位于细胞质中；细胞外外泌体；和脂滴。预计在胞质溶胶和细胞核中有活性。在早期小管中表达；女性相关的生殖结构；男性相关的生殖结构；子房;和睾丸。该基因的人类直系同源物与南美锥虫病有关。与人类 HSPA4（热休克蛋白家族 A (HSP70) 成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in cytoplasm; extracellular exosome; and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (HSP70) member 4). [provided by Alliance of Genome Resources, Apr 2022]