1. Gene
  2. Ndst1 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 Gene

Ndst1 - N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 Gene

种属: Mus musculus

同用名: Hsst; HSNST; N-HSST; NDST-1; HSNST 1; N-HSST 1; b2b2230Clo; 1200015G06Rik

基因 ID: 15531 | 基因类型: protein coding

关于 Ndst1

功能概要

Enables deacetylase activity and sulfotransferase activity. Acts upstream of or within several processes, including animal organ development; positive regulation of signal transduction; and protein sulfation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; future brain; integumental system; nervous system; and respiratory system. Used to study DiGeorge syndrome; congenital diaphragmatic hernia; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndst1 基因产物(6)

mRNA Protein Name
NM_001348100.1 NP_001335029.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348101.1 NP_001335030.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348102.1 NP_001335031.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348103.1 NP_001335032.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
NM_001348146.1 NP_001335075.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2
NM_008306.5 NP_032332.2 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acetylglucosamine deacetylase activity IDA
IDA: 通过直接分析推断
11087757 MGI
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
IDA: 通过直接分析推断
10758005 MGI
enables deacetylase activity IDA
IDA: 通过直接分析推断
11087757 MGI
enables heparan sulfate N-deacetylase activity IDA
IDA: 通过直接分析推断
10758005 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18337501 MGI
enables sulfotransferase activity IDA
IDA: 通过直接分析推断
11087757 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
10664446 MGI
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within cardiac septum development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within cell population proliferation IMP
IMP: 通过突变表型推断
26024086 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within embryo development IGI
IGI: 通过遗传相互作用推断
16020517 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within embryonic viscerocranium morphogenesis IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
16020517 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within glycosaminoglycan metabolic process IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: 通过直接分析推断
18487608 MGI
involved in heparan sulfate proteoglycan biosynthetic process IMP
IMP: 通过突变表型推断
18385133 MGI
involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
IDA: 通过直接分析推断
10758005 MGI
acts upstream of or within midbrain development IGI
IGI: 通过遗传相互作用推断
16020517 MGI
acts upstream of or within polysaccharide biosynthetic process IMP
IMP: 通过突变表型推断
10852901 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
16020517 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
16020517 MGI
acts upstream of or within protein sulfation IMP
IMP: 通过突变表型推断
10852901 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: 通过突变表型推断
10664446 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Golgi apparatus IDA
IDA: 通过直接分析推断
11687650 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

N-heparan sulfate sulfotransferase 1

[Heparan sulfate]-glucosamine N-sulfotransferase 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ndst1 NCBI NCBI:3340