CYP2C18 - cytochrome P450 family 2 subfamily C member 18 Gene

中文名称：细胞色素 P450 家族 2 亚家族 C 成员 18

种属: Homo sapiens

同用名: CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C

关于 CYP2C18

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。该蛋白定位于内质网，但其特异性底物尚未确定。该基因位于染色体 10q24 上的细胞色素 P450 基因簇内。另一个基因 CYP2C17 曾被认为存在；然而，CYP2C17 现在被认为是基于 CYP2C18 和 CYP2C19 的嵌合体的产物。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]