AP2A1 - adaptor related protein complex 2 subunit alpha 1 Gene

中文名称：适配器相关蛋白复合物 2 亚基 alpha 1

种属: Homo sapiens

同用名: ADTAA; CLAPA1; AP2-ALPHA

关于 AP2A1

功能概要

该基因编码在网格蛋白包被的囊泡中发现的衔接蛋白 2 (AP-2) 复合物的 alpha 1 衔接蛋白亚基。 AP-2 复合体是一种异四聚体，由两个大适应蛋白 (α 或β) 、一个中等适应蛋白 (mu) 和一个小适应蛋白 (sigma) 组成。该复合物是包被囊泡细胞质面上蛋白质包被的一部分，它将网格蛋白连接到囊泡中的受体。该基因的可变剪接导致编码两种不同亚型的两种转录变体。已经描述了第三个转录本变体，但其全长性质尚未确定。[RefSeq 提供，2008 年 7 月]

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]