2. Gene
  3. Il6st - interleukin 6 signal transducer Gene

Il6st - interleukin 6 signal transducer Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD130; gp130; D13Ertd699e; 5133400A03Rik

基因 ID: 16195 | 基因类型: protein coding

关于 Il6st

功能概要

Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach Cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st 基因产物(1)

mRNA Protein Name
NM_010560.3 NP_034690.3 interleukin-6 receptor subunit beta precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to interleukin-11 binding IDA
IDA: 通过直接分析推断
7957045 MGI
contributes to interleukin-11 receptor activity IDA
IDA: 通过直接分析推断
7957045 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16452727 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
7957045 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: 通过突变表型推断
10205167 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: 通过直接分析推断
25731159 MGI
involved in intestinal epithelial cell development IDA
IDA: 通过直接分析推断
25731159 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
25731159 MGI
acts upstream of or within positive regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
10486560 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15051883 MGI
acts upstream of or within regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
12629177 MGI
acts upstream of or within signal transduction IDA
IDA: 通过直接分析推断
12147685 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
10989258 MGI
located in dendrite IDA
IDA: 通过直接分析推断
10989258 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
11275690 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
10989258 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-6 receptor subunit beta

IL-6 receptor subunit beta

IL-6R subunit beta

IL-6R-beta

IL-6RB

membrane glycoprotein 130

oncostatin-M receptor subunit alpha

重组 Il6st 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76370 gp130/IL6ST Protein, Mouse (HEK293, Fc) Q00560/NP_034690 (Q23-E617) ≥95%
HY-P76371 gp130/IL6ST Protein, Mouse (HEK293, His) Q00560/NP_034690 (Q23-E617) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06778 IL6ST Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il6st NCBI NCBI:3572
Rattus norvegicus Il6st NCBI NCBI:25205
Macaca mulatta Il6st NCBI NCBI:574127
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