2. Gene
  3. Il7r - interleukin 7 receptor Gene

Il7r - interleukin 7 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CD127; IL-7Ralpha

基因 ID: 16197 | 基因类型: protein coding

关于 Il7r

功能概要

Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]

Il7r 基因产物(2)

mRNA Protein Name
NM_001355680.1 NP_001342609.1 interleukin-7 receptor subunit alpha isoform 2 precursor
NM_008372.4 NP_032398.3 interleukin-7 receptor subunit alpha isoform 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
15909309 MGI
acts upstream of or within B cell proliferation IGI
IGI: 通过遗传相互作用推断
15909309 MGI
acts upstream of or within B cell proliferation IMP
IMP: 通过突变表型推断
15909309 MGI
acts upstream of or within T cell differentiation IGI
IGI: 通过遗传相互作用推断
9215624 MGI
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
9215624 MGI
acts upstream of T cell differentiation in thymus IMP
IMP: 通过突变表型推断
9215626 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
9215624 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9215624 MGI
acts upstream of or within cell morphogenesis IGI
IGI: 通过遗传相互作用推断
15909309 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
20364087 MGI
acts upstream of gene expression IMP
IMP: 通过突变表型推断
18958875 MGI
acts upstream of or within immunoglobulin production IGI
IGI: 通过遗传相互作用推断
15909309 MGI
acts upstream of or within lymph node development IMP
IMP: 通过突变表型推断
12732660 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
9215624 MGI
acts upstream of or within negative regulation of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
9215624 MGI
acts upstream of or within positive regulation of T cell differentiation in thymus IMP
IMP: 通过突变表型推断
9215626 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
18958875 MGI
acts upstream of or within regulation of cell size IDA
IDA: 通过直接分析推断
15909309 MGI
acts upstream of or within regulation of cell size IGI
IGI: 通过遗传相互作用推断
15909309 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12714519 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-7 receptor subunit alpha

IL-7 receptor alpha chain

IL-7 receptor subunit alpha

IL-7R subunit alpha

IL-7R-alpha

IL-7RA

interleukin 7 receptor alpha chain

重组 Il7r 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72536 CD127/IL-7RA Protein, Mouse (HEK293, Fc) P16872 (E21-D239) ≥95%
HY-P76436 CD127/IL-7RA Protein, Mouse (HEK293, His) P16872 (E21-D239) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99412 Lusvertikimab Antagonist 99.41% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163289 TSLP binder-1 / 否
HY-RS06780 IL7R Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il7r NCBI NCBI:3575
Macaca fascicularis Il7r NCBI NCBI:102143679
Rattus norvegicus Il7r NCBI NCBI:294797
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