1. Gene
  2. DEDD2 - death effector domain containing 2 Gene

DEDD2 - death effector domain containing 2 Gene

中文名称:含死亡效应域 2

种属: Homo sapiens

同用名: FLAME3; FLAME-3

基因 ID: 162989 | 基因类型: protein coding

关于 DEDD2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,198,598-42,220,134 (from NCBI)

This gene has 13 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.8), spleen (RPKM 9.9) and 25 other tissues.

功能概要

该基因编码含有死亡效应结构域 (DED) 的核定位蛋白。编码的蛋白质可以在死亡受体诱导的细胞凋亡过程中调节半胱天冬酶和其他蛋白质向细胞核的运输。可变剪接导致多个转录本变体。[RefSeq 提供,2012 年 7 月]

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and Other proteins into the nucleus during death receptor-induced Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

DEDD2 基因产物(3)

mRNA Protein Name
NM_001270614.2 NP_001257543.1 DNA-binding death effector domain-containing protein 2 isoform 1
NM_001270615.2 NP_001257544.1 DNA-binding death effector domain-containing protein 2 isoform 2
NM_133328.4 NP_579874.1 DNA-binding death effector domain-containing protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11741985 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic nuclear changes IDA
IDA: 通过直接分析推断
11741985 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
11741985 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11741985 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
11741985 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DEDD2 蛋白结构

DED

DED: Death effector domain (26 - 109)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

DNA-binding death effector domain-containing protein 2

DED-containing protein FLAME-3

关联疾病

疾病名称 别名
Leukorrhea

Discharge - Leukorrhea

Leukorrhea Of Vagina

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DEDD2 MGD MGI:1914629
Bos taurus DEDD2 VGNC VGNC:27985
Felis catus DEDD2 VGNC VGNC:61424
Macaca mulatta DEDD2 VGNC VGNC:109614
Canis familiaris DEDD2 VGNC VGNC:39873
Rattus norvegicus DEDD2 RGD RGD:1588968