2. Gene
  3. Itgam - integrin alpha M Gene

Itgam - integrin alpha M Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik

基因 ID: 16409 | 基因类型: protein coding

关于 Itgam

功能概要

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of Integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (Integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]

Itgam 基因产物(3)

mRNA Protein Name
NM_001082960.1 NP_001076429.1 integrin alpha-M isoform 1 precursor
NM_008401.2 NP_032427.2 integrin alpha-M isoform 2 precursor
NM_008401.2 NP_032427.2 integrin alpha-M isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cargo receptor activity IGI
IGI: 通过遗传相互作用推断
22438044 MGI
contributes to cargo receptor activity IMP
IMP: 通过突变表型推断
20199584 MGI
enables complement component C3b binding IGI
IGI: 通过遗传相互作用推断
20199584 MGI
enables heparan sulfate proteoglycan binding IDA
IDA: 通过直接分析推断
8043862 MGI
enables heparin binding IDA
IDA: 通过直接分析推断
8043862 MGI
enables opsonin binding IDA
IDA: 通过直接分析推断
12163569 MGI
enables opsonin binding IMP
IMP: 通过突变表型推断
12163569 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
28228282 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within activated T cell proliferation IMP
IMP: 通过突变表型推断
15210787 MGI
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
20199584 MGI
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
22438044 MGI
acts upstream of or within cell adhesion IGI
IGI: 通过遗传相互作用推断
19342649 MGI
acts upstream of or within cell adhesion IMP
IMP: 通过突变表型推断
10528208 MGI
acts upstream of or within cell-cell adhesion IGI
IGI: 通过遗传相互作用推断
16093349 MGI
acts upstream of or within cellular extravasation IMP
IMP: 通过突变表型推断
10528208 MGI
involved in complement receptor mediated signaling pathway IMP
IMP: 通过突变表型推断
22632727 MGI
involved in complement-mediated synapse pruning IMP
IMP: 通过突变表型推断
22632727 MGI
involved in forebrain development IDA
IDA: 通过直接分析推断
18685038 MGI
involved in leukocyte adhesion to vascular endothelial cell IMP
IMP: 通过突变表型推断
8986723 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
8562500 MGI
acts upstream of or within leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
23550035 MGI
acts upstream of or within microglia development IDA
IDA: 通过直接分析推断
20578039 MGI
involved in microglial cell activation IMP
IMP: 通过突变表型推断
18981141 MGI
involved in negative regulation of dopamine metabolic process IDA
IDA: 通过直接分析推断
18981141 MGI
involved in neutrophil apoptotic process IMP
IMP: 通过突变表型推断
8986723 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: 通过突变表型推断
10528208 MGI
involved in phagocytosis IMP
IMP: 通过突变表型推断
8986723 MGI
involved in phagocytosis, engulfment IMP
IMP: 通过突变表型推断
20199584 MGI
involved in positive regulation of mast cell differentiation IMP
IMP: 通过突变表型推断
9862668 MGI
involved in positive regulation of microglial cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
18685038 MGI
involved in positive regulation of prostaglandin-E synthase activity IMP
IMP: 通过突变表型推断
18981141 MGI
involved in positive regulation of protein targeting to membrane IMP
IMP: 通过突变表型推断
18981141 MGI
involved in positive regulation of superoxide anion generation IDA
IDA: 通过直接分析推断
18685038 MGI
involved in positive regulation of superoxide anion generation IMP
IMP: 通过突变表型推断
18981141 MGI
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
20199584 MGI
involved in vertebrate eye-specific patterning IMP
IMP: 通过突变表型推断
22632727 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
9324354 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8043862 MGI
part of integrin alphaM-beta2 complex IMP
IMP: 通过突变表型推断
20199584 MGI
located in membrane IDA
IDA: 通过直接分析推断
12529407 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15138196 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
8986723 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin alpha-M

CD11 antigen-like family member B

CD11B (p170)

CR-3 alpha chain

Mac-1 alpha

cell surface glycoprotein MAC-1 alpha subunit

cell surface glycoprotein MAC-1 subunit alpha

complement receptor type 3

leukocyte adhesion receptor MO1

macrophage antigen a

Itgam 抗体

目录号 产品名 应用 反应物种
HY-P80592 CD11b Antibody WB, IP Mouse
HY-P83690 CD11b Antibody (YA3423) WB, IHC-P, ICC/IF, IP, FC Human

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06960 ITGAM Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itgam NCBI NCBI:3684
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z