DDOST - dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Gene

中文名称：多萜基二磷酸低聚糖--蛋白糖基转移酶非催化亚基

种属: Homo sapiens

同用名: OST; WBP1; AGER1; CDG1R; GATD6; OST48; OKSWcl45

基因 ID: 1650 | 基因类型: protein coding

关于 DDOST

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,651,777-20,661,369 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 112.6), placenta (RPKM 100.3) and 25 other tissues.

功能概要

该基因编码寡糖转移酶复合物的一个组分，该酶复合物催化高甘露糖寡糖转移到粗面内质网腔内新生多肽上的天冬酰胺残基。蛋白质复合物与核糖体共同纯化。该基因的产物还涉及晚期糖基化终产物 (AGEs) 的加工，后者由糖和蛋白质或脂质之间的非酶促反应形成，与衰老和高血糖有关。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

DDOST 基因产物(1)

mRNA	Protein	Name
NM_005216.5	NP_005207.3	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme activator activity	IMP IMP: 通过突变表型推断	22467853	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T cell activation	IDA IDA: 通过直接分析推断	9642163	GOA
involved in protein N-linked glycosylation	IDA IDA: 通过直接分析推断	9642163	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: 通过突变表型推断	22467853	GOA
involved in regulation of protein stability	IMP IMP: 通过突变表型推断	22467853	GOA
involved in response to cytokine	IDA IDA: 通过直接分析推断	9642163	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in intracellular membrane-bounded organelle	IDA IDA: 通过直接分析推断	9642163	GOA
part of oligosaccharyltransferase complex	IDA IDA: 通过直接分析推断	9642163	GOA
part of oligosaccharyltransferase complex	IPI IPI: 通过物理相互作用推断	31831667	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DDOST 蛋白结构

DDOST_48kD

0
100
200
300
400
456 a.a.

蛋白主名

其他名称

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

advanced glycation end-product receptor 1

重组 DDOST 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75701	DDOST Protein, Human	P39656-1 (S43-P427)	≥95%

关联疾病

疾病名称

别名

Congenital Disorder Of Glycosylation, Type Ir

Congenital Disorder Of Glycosylation Type Ir	CDG1R
Cdg Ir	Cdgir
Congenital Disorder Of Glycosylation 1r	Cdg-Ir
Congenital Disorder Of Glycosylation Ir	Ddost-Cdg
Cdg Syndrome Type Ir	Carbohydrate Deficient Glycoprotein Syndrome Type Ir
Congenital Disorder Of Glycosylation Type 1r	Glycosylation, Congenital Disorder Of, Type Ir

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03619	DDOST Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DDOST	MGD	MGI:1194508
Macaca mulatta	DDOST	VGNC	VGNC:71757
Bos taurus	DDOST	VGNC	VGNC:27952
Felis catus	DDOST	VGNC	VGNC:61394
Rattus norvegicus	DDOST	RGD	RGD:1308970
Canis familiaris	DDOST	VGNC	VGNC:39841
Others	DDOST	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DDOST - dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Gene

关于 DDOST

功能概要

DDOST 基因产物(1)

DDOST 蛋白结构

重组 DDOST 蛋白

关联疾病

直系同源

热门区域

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DDOST - dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Gene

关于 DDOST

功能概要

DDOST 基因产物(1)

DDOST 蛋白结构

重组 DDOST 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z