CRISP1 - cysteine rich secretory protein 1 Gene

中文名称：富半胱氨酸的分泌蛋白 1

种属: Homo sapiens

同用名: ARP; AEGL1; HUMARP; CRISP-1; HEL-S-57; HSCRISP1D; HSCRISP1G

关于 CRISP1

功能概要

受精由一系列特定的细胞间相互作用组成，最终导致精子和卵子质膜融合。识别、结合和融合是通过位于精子和卵子质膜特定区域的互补分子的相互作用而发生的。在精子中，顶体后区或赤道段参与精卵质膜融合。由该基因编码的蛋白质是富含半胱氨酸的分泌蛋白 (CRISP) 家族的成员。它在附睾中表达，分泌到附睾腔内，并结合到精子头部的顶体后区域，在精卵融合中发挥作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 3 月]

Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]