2. Gene
  3. Lag3 - lymphocyte-activation gene 3 Gene

Lag3 - lymphocyte-activation gene 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ly66; CD223; LAG-3

基因 ID: 16768 | 基因类型: protein coding

关于 Lag3

功能概要

Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]

Lag3 基因产物(1)

mRNA Protein Name
NM_008479.2 NP_032505.1 lymphocyte activation gene 3 protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class II protein binding IDA
IDA: 通过直接分析推断
12209638 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
30580966 MGI
enables transmembrane signaling receptor activity IDA
IDA: 通过直接分析推断
12209638 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell activation IDA
IDA: 通过直接分析推断
12421911 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
12421911 MGI
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
12209638 MGI
acts upstream of interleukin-2 production IDA
IDA: 通过直接分析推断
12421911 MGI
acts upstream of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
8602528 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
8602528 MGI
acts upstream of or within negative regulation of T cell activation IDA
IDA: 通过直接分析推断
12421911 MGI
involved in negative regulation of T cell activation IDA
IDA: 通过直接分析推断
12209638 MGI
acts upstream of or within negative regulation of interleukin-2 production IDA
IDA: 通过直接分析推断
12421911 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
15485628 MGI
involved in plasmacytoid dendritic cell activation IMP
IMP: 通过突变表型推断
19201841 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
8602528 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
8602528 MGI
involved in regulation of immune response IDA
IDA: 通过直接分析推断
30580966 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8602528 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
17245433 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

lymphocyte activation gene 3 protein

activation-induced cytidine deaminase-linked autoimmunity protein

aida

Lag3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Lag3 Q61790 Fgl1 Mus musculus Q71KU9
BLI
30580966
种属内
Lag3 Q61790 Fgl1 Mus musculus Q71KU9
Array
30580966
种属间
Lag3 Q61790 FGL1 Homo sapiens Q08830
Array
30580966
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Lag3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73843 LAG-3 Protein, Mouse (HEK293, Fc) Q61790/NP_032505.1 (S23-L442) ≥95%
HY-P73844 LAG-3 Protein, Mouse (HEK293) Q61790 (G24-L442) ≥95%
HY-P78720 LAG-3 Protein, Mouse (419a.a, HEK293, His) Q61790 (G24-L442) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (8)
目录号 产品名 作用方式
纯度 Phase
HY-P99156 Relatlimab 98.00% Phase 3
HY-P99573 Tebotelimab 99.52% Phase 3
HY-P99617 Fianlimab 99.04% Phase 3
HY-P99027 Ieramilimab 98.24% Phase 2
HY-P99613 Favezelimab 97.79% Phase 2
HY-P99933 Eftilagimod alfa 95.98% Phase 2
HY-P990046 Tuparstobart / Phase 2
HY-P99736 Miptenalimab / Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144088 ZYF0033 Inhibitor 98.86% 否
HY-162811 LAG-3 biner 1 / 否
HY-145240 eIF4E-IN-1 Inhibitor / 否
HY-149916 A2AR-antagonist-1 Antagonist / 否
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / 否
HY-RS07492 LAG3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164308 SA-15-P Inhibitor / 否
抗体抑制剂 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99141 Anti-Mouse LAG-3 Antibody (C9B7W) 95.00% 否
HY-P99922 Encelimab Inhibitor 95.25% 否
HY-P990700 Tobemstomig / 否
HY-P990912 Cugrastomig / 否
HY-P990968 Alcestobart / 否
HY-P990976 Brivestobart / 否
HY-P99354 Bavunalimab / 否
HY-P990740 Fanastomig / 否
HY-P990750 Negalstobart / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lag3 NCBI NCBI:3902
Macaca fascicularis Lag3 NCBI NCBI:102122272
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