2. Gene
  3. CLEC4C - C-type lectin domain family 4 member C Gene

CLEC4C - C-type lectin domain family 4 member C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：C 型凝集素结构域家族 4 成员 C

种属: Homo sapiens

同用名: DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150

基因 ID: 170482 | 基因类型: protein coding

关于 CLEC4C

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,729,383-7,749,541 (from NCBI)

This gene has 6 transcripts (splice variants), 747 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 1.5), spleen (RPKM 0.9) and 6 other tissues.

功能概要

该基因编码 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。该家族的成员具有共同的蛋白质折叠并具有多种功能，例如细胞粘附、细胞间信号传导、糖蛋白转换以及在炎症和免疫反应中的作用。编码的 2 型跨膜蛋白可能在树突状细胞功能中发挥作用。已经为该基因鉴定了编码不同亚型的两个转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC4C 基因产物(4)

mRNA Protein Name
NM_001371390.1 NP_001358319.1 C-type lectin domain family 4 member C isoform 1
NM_001371391.1 NP_001358320.1 C-type lectin domain family 4 member C isoform 3
NM_130441.3 NP_569708.1 C-type lectin domain family 4 member C isoform 1
NM_203503.2 NP_987099.1 C-type lectin domain family 4 member C isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLEC4C 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (102 - 208)

  • 0
  • 100
  • 200
  • 213 a.a.
蛋白主名 其他名称

C-type lectin domain family 4 member C

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11

重组 CLEC4C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71679 CLEC4C Protein, Human (HEK293, His, Myc) Q8WTT0-1 (N45-I213) ≥95%
HY-P72014 CLEC4C Protein, Human (His-SUMO) Q8WTT0-1 (N45-I213) ≥95%
HY-P78387 CLEC4C Protein, Human (Biotinylated, HEK293, His-Avi) Q8WTT0-1 (F46-I213) ≥95%

关联疾病

疾病名称 别名
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

Left Ventricular Noncompaction 3

Dilated Cardiomyopathy 1c

CMD1C

Cardiomyopathy, Hypertrophic, 24

Dilated Cardiomyopathy With Left Ventricular Noncompaction

Cardiomyopathy, Dilated, 1c, With Or Without Lvnc

Cmdc1

Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction

Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction

Cardiomyopathy Dilated With Left Ventricular Noncompaction

Cardiomyopathy, Familial Hypertrophic 24

CMH24

Left Ventricular Non-Compaction 3

LVNC3

Cardiomyopathy, Dilated 1c

Familial Hypertrophic Cardiomyopathy 24

Cardiomyopathy, Dilated, 1c
Inflammatory Bowel Disease 23

IBD23
Pitt-Hopkins Syndrome

PTHS

Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

Mental Retardation, Syndromal, With Intermittent Hyperventilation

Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

Pitt Hopkins Syndrome

Phs

Encephalopathy Severe Epileptic With Autonomic Dysfunction
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02792 CLEC4C Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990373 Anti-CLEC4C Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CLEC4C MGD MGI:1917060
Rattus norvegicus CLEC4C RGD RGD:1359354
Macaca mulatta CLEC4C VGNC VGNC:99915
Macaca fascicularis CLEC4C NCBI NCBI:102147129
Others CLEC4C NCBI
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