SLC40A1 - solute carrier family 40 member 1 Gene

中文名称：溶质载体家族 40 成员 1

种属: Rattus norvegicus

同用名: Fpn1; Slc11a3; Slc39a1

关于 SLC40A1

功能概要

预测该基因编码的蛋白编码的蛋白可启动二价铁跨膜转运体活性；相同的蛋白质结合活性；和肽激素结合活性。预计参与细胞铁离子稳态和跨质膜的铁离子输出。预计在多个过程的上游或内部起作用，包括多细胞有机体铁离子稳态；通过 RNA 聚合酶 II 调节转录；和脾小梁的形成。预计位于几种细胞成分中，包括细胞质；核质；和突触小泡。预计在基底外侧质膜中有活性。该基因的人类直系同源物与 4 型血色素沉着症有关。与人类 SLC40A1（溶质载体家族 40 成员 1）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in cellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal iron ion homeostasis; regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1). [provided by Alliance of Genome Resources, Apr 2022]