Mknk2 - MAP kinase-interacting serine/threonine kinase 2 Gene

中文名称：MAP 激酶相互作用的 丝氨酸/苏氨酸激酶 2

种属: Mus musculus

同用名: Mnk2; Gprk7; 2010016G11Rik

关于 Mknk2

功能概要

由该基因编码的蛋白质是一种丝氨酸/苏氨酸蛋白激酶，它是细胞外信号调节激酶和 p38 丝裂原活化蛋白激酶途径的目标。该酶靶向多种底物，包括真核翻译起始因子 4E 和雷帕霉素的哺乳动物靶标，它们受其磷酸化的负调控。无效突变小鼠不表现出发育或生殖缺陷。然而，该蛋白和丝裂原活化蛋白激酶相互作用丝氨酸/苏氨酸蛋白激酶 1 均无效的小鼠在磷酸酶和张力蛋白同系物突变小鼠中延迟了肿瘤发展，表明该基因在肿瘤发展中具有致癌功能。 [RefSeq 提供，2014 年 10 月]

The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This Enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in Phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]