MKNK2 - MAPK interacting serine/threonine kinase 2 Gene

中文名称：MAPK 相互作用的丝氨酸/苏氨酸激酶 2

种属: Homo sapiens

同用名: MNK2; GPRK7

关于 MKNK2

功能概要

该基因编码钙/钙调蛋白依赖性蛋白激酶 (CaMK) Ser/Thr 蛋白激酶家族的成员，属于蛋白激酶超家族。该蛋白质包含保守的 DLG (asp-leu-gly) 和 ENIL (glu-asn-ile-leu) 基序，以及一个结合输入蛋白 A 和翻译因子支架蛋白真核起始因子 4G (eIF4G) 的 N 末端多元区。该蛋白是由丝裂原活化蛋白 (MAP) 激酶激活的下游激酶之一。它磷酸化真核起始因子 4E (eIF4E) ，从而在 mRNA 翻译起始、致癌转化和恶性细胞增殖中发挥重要作用。除 eIF4E 外，该蛋白还与 von Hippel-Lindau 肿瘤抑制因子 (VHL) 、ring-box 1 (Rbx1) 和 Cullin2 (Cul2) 相互作用，它们都是 CBC (VHL) 泛素连接酶 E3 复合物的组成部分。已发现多个选择性剪接的转录本变体，但仅确定了两个变体的全长性质和生物活性。这两种变体编码不同的亚型，这些亚型在活性和调节以及亚细胞定位方面不同。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CaMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin Ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]