Mmp10 - matrix metallopeptidase 10 Gene

中文名称：基质金属肽酶 10

种属: Mus musculus

同用名: SL-2; MMP-10

关于 Mmp10

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶。小鼠体内编码蛋白的缺乏促进了实验性肺癌的形成，加剧了实验性结肠炎并促进了与炎症相关的结肠发育不良的发展。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. The lack of encoded protein in mice promotes experimental lung Cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]