DMBT1 - deleted in malignant brain tumors 1 Gene

中文名称：在恶性脑瘤中缺失 1

种属: Homo sapiens

同用名: SAG; GP340; SALSA; muclin

基因 ID: 1755 | 基因类型: protein coding

关于 DMBT1

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:122,560,754-122,643,736 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and 15 paralogues. Biased expression in duodenum (RPKM 482.0), small intestine (RPKM 157.2) and 1 other tissue.

功能概要

人类染色体 10q 序列的丢失与人类癌症的进展有关。该基因最初是根据其在髓母细胞瘤细胞系中的缺失而分离出来的。该基因在胎儿肺中以 6.0、7.5 和 8.0 kb 的转录物表达，在成人肺中以 8.0 kb 的转录物表达，尽管 7.5 kb 的转录物尚未表征。编码的蛋白质前体是一种糖蛋白，包含多个清道夫受体富含半胱氨酸 (SRCR) 域，由 SRCR 散布域 (SID) 分隔。转录变体 2 (8.0 kb) 已被证明可独立于碳水化合物识别而结合表面活性剂蛋白 D。这表明 DMBT1 可能不是经典的抑癌基因，而是在肿瘤细胞与免疫系统的相互作用中发挥作用。[RefSeq 提供，2016 年 3 月]

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016]

DMBT1 基因产物(5)

mRNA	Protein	Name
NM_001320644.2	NP_001307573.1	deleted in malignant brain tumors 1 protein isoform d precursor
NM_001377530.1	NP_001364459.1	deleted in malignant brain tumors 1 protein isoform e precursor
NM_004406.3	NP_004397.2	deleted in malignant brain tumors 1 protein isoform a precursor
NM_007329.3	NP_015568.2	deleted in malignant brain tumors 1 protein isoform b precursor
NM_017579.3	NP_060049.2	deleted in malignant brain tumors 1 protein isoform c precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	19189310	GOA
enables heparan sulfate binding	IDA IDA: 通过直接分析推断	19189310	GOA
enables lipopolysaccharide binding	IDA IDA: 通过直接分析推断	19189310	GOA
enables lipoteichoic acid binding	IDA IDA: 通过直接分析推断	19189310	GOA
enables pattern recognition receptor activity	IDA IDA: 通过直接分析推断	19189310	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10101009	GOA
enables scavenger receptor activity	IDA IDA: 通过直接分析推断	19189310	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	11007786	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: 通过突变表型推断	19189310	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: 通过突变表型推断	11007786	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	11007786	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: 通过突变表型推断	11007786	GOA
involved in induction of bacterial agglutination	IDA IDA: 通过直接分析推断	11007786	GOA
involved in induction of bacterial agglutination	IMP IMP: 通过突变表型推断	11007786	GOA
involved in receptor-mediated endocytosis	IDA IDA: 通过直接分析推断	19189310	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10485905	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	11007786	GOA
located in phagocytic vesicle membrane	IDA IDA: 通过直接分析推断	10485905	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DMBT1 蛋白结构

SRCR

CUB

SRCR

CUB

Zona_pellucida

0
400
800
1200
1600
2000
2413 a.a.

蛋白主名

其他名称

deleted in malignant brain tumors 1 protein

glycoprotein 340

重组 DMBT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75710	DMBT1 Protein, Human (HEK293, His)	Q9UGM3/NP_004397.2 (T20-S220)	≥95%

关联疾病

疾病名称

别名

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Brain Cancer

Adult Brain Tumor	Malignant Neoplasm Of Brain
Brain Neoplasms	Brain Neoplasm
Neoplasm Of Brain	Primary Malignant Neoplasm Of Brain
Brain Tumors	Adult Malignant Brain Neoplasm
Brain Neoplasm, Adult	Bt - Brain Tumour
Malignant Brain Tumour	Malignant Primary Brain Neoplasm
Malignant Primary Brain Tumor	Malignant Tumor Of Adult Brain
Malignant Tumor Of Brain	Primary Brain Neoplasm
Primary Brain Tumor	Tumor Of The Brain
Brain Tumor, Adult	Brain Tumor Primary
Malignant Primary Brain Tumors	Primary Brain Tumors
Cancer, Brain	Brain Tumor, Primary

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Glioma

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Enamel Caries

Primary Dental Caries	Dental Caries Limited To Enamel
Simple Dental Cavity

High Grade Glioma

Malignant Glioma	Glial Cell Tumor
Glioma, Malignant	Malignant Neuroglial Tumor
Neuroglial Tumor	Glioma
Malignant Gliomas

Oligodendroglioma

Oligodendroglial Neoplasm	Oligodendroglial Tumor
Oligodendroglial Tumors	Well Differentiated Oligodendroglioma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03820	DMBT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DMBT1	VGNC	VGNC:39996
Mus musculus	DMBT1	MGD	MGI:106210
Rattus norvegicus	DMBT1	RGD	RGD:61984

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DMBT1 - deleted in malignant brain tumors 1 Gene

关于 DMBT1

功能概要

DMBT1 基因产物(5)

DMBT1 蛋白结构

重组 DMBT1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DMBT1 - deleted in malignant brain tumors 1 Gene

关于 DMBT1

功能概要

DMBT1 基因产物(5)

DMBT1 蛋白结构

重组 DMBT1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z