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  2. Mtnr1a - melatonin receptor 1A Gene

Mtnr1a - melatonin receptor 1A Gene

中文名称:褪黑激素受体 1A

种属: Mus musculus

同用名: MR; MelR

基因 ID: 17773 | 基因类型: protein coding

关于 Mtnr1a

Chromosome 8: 45,522,174-45,541,543 forward strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 185 orthologues, 55 paralogues and is associated with 8 phenotypes. Biased expression in testis adult (RPKM 1.3), liver adult (RPKM .1) and 3 other tissues.

功能概要

预测该基因编码的蛋白可启动激素结合活性;褪黑激素受体活性;和有机环状化合物结合活性。预计参与腺苷酸环化酶抑制G蛋白偶联受体信号通路;昼夜节律;和胰岛素分泌的负调节。预测作用于信号转导的上游或内部。预测位于神经细胞体。预计是质膜的组成部分。预计是受体复合体的一部分。预计在质膜上有活性。以多种结构表达,包括肾上腺;脑;性腺;肠;以及肝脏和胆道系统。与人类 MTNR1A(褪黑激素受体 1A)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable hormone binding activity; Melatonin Receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of Insulin secretion. Predicted to act upstream of or within signal transduction. Predicted to be located in neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gonad; intestine; and liver and biliary system. Orthologous to human MTNR1A (Melatonin Receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1a 基因产物(1)

mRNA Protein Name
NM_008639.3 NP_032665.1 melatonin receptor type 1A

Mtnr1a 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (30 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (32 - 56)

7tm_GPCRs

7tm_GPCRs: cd14964 (65 - 87)

7tm_GPCRs

7tm_GPCRs: cd14964 (103 - 125)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (187 - 210)

7tm_GPCRs

7tm_GPCRs: cd14964 (239 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

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  • 353 a.a.
蛋白主名 其他名称

melatonin receptor type 1A

Mel1a receptor

mel-1A-R

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mtnr1a NCBI NCBI:4543