Nos1 - nitric oxide synthase 1, neuronal Gene

中文名称：一氧化氮合酶 1 ，神经元

种属: Mus musculus

同用名: NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

关于 Nos1

功能概要

该基因编码的蛋白可启动一氧化氮合酶活性。参与多个过程，包括一氧化氮生物合成过程；参与心脏过程的腺苷酸环化酶激活肾上腺素能受体信号通路的正向调控；氮化合物代谢过程的正向调控。作用于多个过程的上游或内部，包括肽基-半胱氨酸 S-亚硝基化； RNA 聚合酶 II 对转录的正调控；和调节金属离子传输。位于多个细胞成分中，包括 T 管； Z盘；和肌浆网膜。在 Held 的花萼中活跃。与小窝共定位。以多种结构表达，包括消化系统；泌尿生殖系统；外皮系统；神经系统;和感觉器官。用于研究贲门失弛缓症和肥厚性幽门狭窄。该基因的人类直系同源物与阿尔茨海默病有关；帕金森病；哮喘;囊性纤维化;和肥厚性幽门狭窄。与人 NOS1（一氧化氮合酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in heart process; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]