2. Gene
  3. Notch4 - notch 4 Gene

Notch4 - notch 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: N4; Int3; Int-3

基因 ID: 18132 | 基因类型: protein coding

关于 Notch4

功能概要

Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and positive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (Notch receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Notch4 基因产物(1)

mRNA Protein Name
NM_010929.2 NP_035059.2 neurogenic locus notch homolog protein 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
24667410 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9111338 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
11344305 MGI
involved in morphogenesis of a branching structure IMP
IMP: 通过突变表型推断
11344305 MGI
acts upstream of or within negative regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
24667410 MGI
involved in negative regulation of endothelial cell differentiation IMP
IMP: 通过突变表型推断
11344305 MGI
acts upstream of or within positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
24667410 MGI
acts upstream of or within positive regulation of aorta morphogenesis IMP
IMP: 通过突变表型推断
18952909 MGI
acts upstream of or within regulation of Notch signaling pathway IGI
IGI: 通过遗传相互作用推断
24667410 MGI
acts upstream of or within regulation of protein localization IDA
IDA: 通过直接分析推断
24667410 MGI
acts upstream of or within regulation of protein processing IDA
IDA: 通过直接分析推断
24667410 MGI
involved in vasculature development IMP
IMP: 通过突变表型推断
11344305 MGI
acts upstream of or within venous blood vessel morphogenesis IMP
IMP: 通过突变表型推断
18952909 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
24667410 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24667410 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurogenic locus notch homolog protein 4

Notch gene homolog 4

Notch4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Notch4 P31695 sel-10 Caenorhabditis elegans Q93794
Anti Bait CoIP
9389650
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Notch4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P701028 Notch 4 Protein, Mouse (HEK293, His) P31695 (E1042-L1441) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-15670 BMS-906024 Inhibitor 98.10% Phase 1
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09452 NOTCH4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Notch4 NCBI NCBI:4855
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