Nras - neuroblastoma ras oncogene Gene

中文名称：神经母细胞瘤ras癌基因

种属: Mus musculus

同用名: N-ras

关于 Nras

功能概要

预测该基因编码的蛋白可启动 GDP 绑定活动； GTP结合活性；和 GTPase 活性。参与血管生成的正向调节。作用于多个过程的上游或内部，包括 T 细胞受体信号通路；对原生动物的防御反应；和干扰素-γ 产生的正向调节。位于膜内。以多种结构表达，包括消化系统；脑;心血管系统;眼睛;和泌尿生殖系统。该基因的人类直系同源物与多种疾病有关，包括努南综合征 6；自身免疫性淋巴增生综合征 4 型；内分泌腺癌（多发）；血液系统癌症（多发性）；和生殖器官癌（多发性）。与人类 NRAS（NRAS 原癌基因，GTPase）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]