1. Gene
  2. Pik3c2g - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

Pik3c2g - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

中文名称:磷脂酰肌醇 4-磷酸 3-激酶催化亚基 2 型 γ

种属: Mus musculus

同用名: PI3K-C2-gamma

基因 ID: 18705 | 基因类型: protein coding

关于 Pik3c2g

Chromosome 6: 139,564,219-139,915,010 forward strand.GRCm39:CM000999.3

This gene has 15 transcripts (splice variants), 183 orthologues, 9 paralogues and is associated with 13 phenotypes. Biased expression in kidney adult (RPKM 1.6), liver adult (RPKM 1.3) and 13 other tissues.

功能概要

预测该基因编码的蛋白具有 1-磷脂酰肌醇 3-激酶活性和 1-磷脂酰肌醇 4-磷酸 3-激酶活性。参与趋化性。预测位于高尔基体和核膜。预计是磷脂酰肌醇 3-激酶复合物的一部分。预计在细胞质和质膜中有活性。在消化系统中表达;中枢神经系统;肝;和视网膜。该基因的人类直系同源物与 2 型糖尿病有关。与人 PIK3C2G(phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 γ)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in chemotaxis. Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in alimentary system; central nervous system; liver; and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c2g 基因产物(2)

mRNA Protein Name
NM_207683.3 NP_997566.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1
NM_011084.2 NP_035214.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: 通过直接分析推断
9514948 MGI
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
IDA: 通过直接分析推断
9514948 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemotaxis IMP
IMP: 通过突变表型推断
20536348 MGI
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: 通过直接分析推断
9514948 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
9514948 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Pik3c2g 蛋白结构

C2A_PI3K_class_II

C2A_PI3K_class_II: cd04012 (537 - 697)

PI3Ka

PI3Ka: cl00271 (712 - 879)

PI3Kc_C2_gamma

PI3Kc_C2_gamma: cd05177 (885 - 1238)

PX_PI3K_C2_gamma

PX_PI3K_C2_gamma: cd06896 (1267 - 1367)

C2

C2: cl14603 (1389 - 1501)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1506 a.a.
蛋白主名 其他名称

phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

ptdIns-3-kinase C2 subunit gamma

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pik3c2g NCBI NCBI:5288