Prkcb - protein kinase C, beta Gene

中文名称：蛋白激酶 C， β

种属: Mus musculus

同用名: Pkcb; PKC-B; Prkcb1; Prkcb2; PKC-Beta

关于 Prkcb

功能概要

该基因编码的蛋白可启动钙通道调节剂活性和蛋白激酶 C 活性。涉及多个过程，包括化学突触传递的调节； NF-kappaB 转录因子活性的正调控；和信号转导的正调控。作用于多个过程的上游或内部，包括细胞钙离子稳态；细胞对碳水化合物刺激的反应；和对缺氧的反应。位于细胞质中；膜;和核。血影蛋白的一部分。在 Held 的花萼和突触前细胞质中具有活性。以多种结构表达，包括中枢神经系统；泌尿生殖系统；心室;视网膜；和唾液腺。该基因的人类直系同源物与扩张型心肌病和肺非小细胞癌有关。与人 PRKCB（蛋白激酶 C β）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calcium Channel regulator activity and protein kinase C activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; and response to hypoxia. Located in cytoplasm; membrane; and nucleus. Part of spectrin. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; retina; and salivary gland. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]