Ppard - peroxisome proliferator activator receptor delta Gene

中文名称：过氧化物酶体增殖物激活物受体 δ

种属: Mus musculus

同用名: NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta

关于 Ppard

功能概要

该基因编码的蛋白可启动 DNA 结合活性和 DNA 结合转录抑制活性，RNA 聚合酶 II 特异性。参与多个过程，包括成肌细胞分化的负调节；骨骼肌组织再生的正向调节；和基因表达的调控。作用于几个过程的上游或内部，包括角质形成细胞迁移；角质形成细胞增殖；和磷脂酰肌醇 3-激酶信号的正调节。位于染色质和细胞核中。以多种结构表达，包括大脑；早孕;泌尿生殖系统；直觉;和感觉器官。用于研究亨廷顿病和 2 型糖尿病。该基因的人类直系同源物与 2 型糖尿病有关。与人 PPARD（过氧化物酶体增殖物激活受体 delta）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]