2. Gene
  3. Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

Ppargc1a - peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：过氧化物酶体增殖激活受体， γ，辅激活因子 1α

种属: Mus musculus

同用名: Pgc1; PGC-1; Pgco1; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; PPARGC-1-alpha

基因 ID: 19017 | 基因类型: protein coding

关于 Ppargc1a

Chromosome 5: 51,611,592-51,725,068 reverse strand.GRCm39:CM000998.3

This gene has 5 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 99 phenotypes. Broad expression in heart adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 22 other tissues.

功能概要

该基因编码一种转录共激活因子，可诱导和协调基因表达，调节线粒体生物发生、呼吸、肝糖异生、棕色脂肪中的产热程序和肌纤维类型转换。缺乏编码蛋白的小鼠表现出产热能力降低、多动和对饮食诱导的肥胖的抵抗力。心脏中特异性缺乏编码蛋白的小鼠表现出围产期心肌病。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Ppargc1a 基因产物(6)

mRNA Protein Name
NM_001402989.1 NP_001389918.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform d
NM_001402988.1 NP_001389917.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform c
NM_001402991.1 NP_001389920.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402990.1 NP_001389919.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform e
NM_001402987.1 NP_001389916.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b
NM_008904.3 NP_032930.1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15681609 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
19345188 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
17952069 MGI
enables lncRNA binding IPI
IPI: 通过物理相互作用推断
27760051 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14729567 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
17476214 MGI
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
16271724 MGI
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
19345188 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adipose tissue development IMP
IMP: 通过突变表型推断
22237023 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: 通过突变表型推断
20566846 MGI
involved in circadian regulation of gene expression IDA
IDA: 通过直接分析推断
17476214 MGI
acts upstream of energy homeostasis IMP
IMP: 通过突变表型推断
19345188 MGI
involved in energy homeostasis IMP
IMP: 通过突变表型推断
23150719 MGI
involved in gluconeogenesis IDA
IDA: 通过直接分析推断
15716268 MGI
acts upstream of or within mitochondrion organization IDA
IDA: 通过直接分析推断
27760051 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
27760051 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
20566846 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
20566846 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
19651776 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14744933 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20661474 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
15454086 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15199055 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
21106753 MGI
involved in regulation of circadian rhythm IDA
IDA: 通过直接分析推断
17476214 MGI
acts upstream of or within respiratory electron transport chain IDA
IDA: 通过直接分析推断
14744933 MGI
acts upstream of or within response to dietary excess IDA
IDA: 通过直接分析推断
24726645 MGI
acts upstream of or within response to muscle activity IDA
IDA: 通过直接分析推断
20086200 MGI
involved in response to muscle activity IMP
IMP: 通过突变表型推断
21106753 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
17952069 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ppargc1a 蛋白结构

RRM_PPARGC1A

RRM_PPARGC1A: cd12623 (673 - 763)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor gamma coactivator 1-alpha

PPAR-gamma coactivator 1-alpha

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10930 Ppargc1a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10928 PPARGC1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10929 Ppargc1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ppargc1a NCBI NCBI:10891
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