Prkdc - protein kinase, DNA activated, catalytic polypeptide Gene

中文名称：蛋白激酶，DNA 激活，催化多肽

种属: Mus musculus

同用名: p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs

关于 Prkdc

功能概要

该基因编码的蛋白可启动 DNA 依赖性蛋白激酶活性；双链 DNA 结合活性；和酶结合活性。参与多个过程，包括调节细胞蛋白质代谢过程；造血干细胞分化的调节；和调节造血功能。作用于多个过程的上游或内部，包括 DNA 代谢过程；异位生殖细胞程序性细胞死亡；和免疫系统的发育。位于核内。以多种结构表达，包括中枢神经系统；神经视网膜;和胸腺原基。用于研究严重联合免疫缺陷、常染色体隐性遗传、T 细胞阴性、B 细胞阴性、Nk 细胞阳性。该基因与免疫缺陷 26 相关的人类直向同源基因。与人类 PRKDC（蛋白激酶、DNA 激活、催化亚基）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-dependent protein kinase activity; double-stranded DNA binding activity; and Enzyme binding activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of hematopoietic stem cell differentiation; and regulation of hemopoiesis. Acts upstream of or within several processes, including DNA metabolic process; ectopic germ cell programmed cell death; and immune system development. Located in nucleus. Is expressed in several structures, including central nervous system; neural retina; and thymus primordium. Used to study severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]