1. Gene
  2. Pthlh - parathyroid hormone-like peptide Gene

Pthlh - parathyroid hormone-like peptide Gene

种属: Mus musculus

同用名: PLP; Pthrp; PTH-like

基因 ID: 19227 | 基因类型: protein coding

关于 Pthlh

功能概要

This gene encodes a member of the parathyroid family of Hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of Apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active Peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]

Pthlh 基因产物(1)

mRNA Protein Name
NM_008970.4 NP_032996.2 parathyroid hormone-related protein preproprotein
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
11606467 MGI
acts upstream of bone mineralization IMP
IMP: 通过突变表型推断
19968565 MGI
acts upstream of chondrocyte differentiation IMP
IMP: 通过突变表型推断
8895385 MGI
acts upstream of or within endochondral ossification IMP
IMP: 通过突变表型推断
8895385 MGI
acts upstream of or within endoderm development IDA
IDA: 通过直接分析推断
9921650 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
15162506 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: 通过突变表型推断
15162506 MGI
acts upstream of or within mammary gland bud elongation IMP
IMP: 通过突变表型推断
9477327 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IDA
IDA: 通过直接分析推断
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IGI
IGI: 通过遗传相互作用推断
17328886 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
8895385 MGI
acts upstream of or within nipple sheath formation IMP
IMP: 通过突变表型推断
9477327 MGI
acts upstream of or within osteoblast development IMP
IMP: 通过突变表型推断
9832460 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17328886 MGI
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
17328886 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
8314082 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: 通过突变表型推断
15162506 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
8895385 MGI
located in nucleus IDA
IDA: 通过直接分析推断
26859332 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

parathyroid hormone-related protein

PTH-related peptide

parathyroid hormone-like hormone

parathyroid hormone-like protein

parathyroid hormone-related peptide

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pthlh NCBI NCBI:5744