Rara - retinoic acid receptor, alpha Gene

中文名称：视黄酸受体， α

种属: Mus musculus

同用名: RAR; Nr1b1; RARalpha1

关于 Rara

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 转录调节区序列特异性 DNA 结合活性和核受体活性。参与多个过程，包括支持细胞命运决定；细胞对脂多糖的反应；和生殖细胞发育。作用于多个过程的上游或内部，包括动物器官发育；软骨发育的负调节；和调节细胞大分子生物合成过程。位于多个细胞成分中，包括树突；神经细胞体；和核。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；肢;和感觉器官。该基因的人类直系同源物与急性早幼粒细胞白血病有关。与人类 RARA（视黄酸受体 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in several processes, including Sertoli cell fate commitment; cellular response to lipopolysaccharide; and germ cell development. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and regulation of cellular macromolecule biosynthetic process. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]