2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AR7

AR7 是非典型的 RARA/RARα (视黄酸受体 α) 拮抗剂。AR7 特异性激活伴侣介导的自噬 (CMA) 活性，而不会影响自噬。

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AR7 Chemical Structure

AR7 Chemical Structure

CAS No. : 80306-38-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥660
In-stock
1 mg ￥272
In-stock
5 mg ￥596
In-stock
10 mg ￥990
In-stock
25 mg ￥2100
In-stock
50 mg ￥3688
In-stock
100 mg ￥5438
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

AR7 相关抗体

Top Publications Citing Use of Products

    AR7 purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284.  [Abstract]

    After treated with 1 μM AR7 for 3 days, the protein expression of CD11b, CEBPβ is detected by immunobloting and quantified.

    查看 RAR/RXR 亚型特异性产品:

    查看所有亚型
    RXRα RXRβ RXRγ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    HepG2 IC50
    10 μM
    Compound: 11
    Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
    		[PMID: 19515559]
    体外研究
    (In Vitro)

    Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2R1441G KI mutant MEFs[1].
    AR7 (10, 20, 30 uM; 12, 24 hours) has no effect on macroautophagy in NIH 3T3 cells[2].
    Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7 significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    AR7 相关抗体:
    分子量

    257.71

    Formula

    C15H12ClNO
    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 25 mg/mL (97.01 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.8803 mL 19.4017 mL 38.8033 mL
    5 mM 0.7761 mL 3.8803 mL 7.7607 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.38%

    COA (283 KB) HNMR (135 KB) LCMS (104 KB)

    产品使用指南 (1538 KB)
    参考文献

    AR7 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.8803 mL 19.4017 mL 38.8033 mL 97.0083 mL
    5 mM 0.7761 mL 3.8803 mL 7.7607 mL 19.4017 mL
    10 mM 0.3880 mL 1.9402 mL 3.8803 mL 9.7008 mL
    15 mM 0.2587 mL 1.2934 mL 2.5869 mL 6.4672 mL
    20 mM 0.1940 mL 0.9701 mL 1.9402 mL 4.8504 mL
    25 mM 0.1552 mL 0.7761 mL 1.5521 mL 3.8803 mL
    30 mM 0.1293 mL 0.6467 mL 1.2934 mL 3.2336 mL
    40 mM 0.0970 mL 0.4850 mL 0.9701 mL 2.4252 mL
    50 mM 0.0776 mL 0.3880 mL 0.7761 mL 1.9402 mL
    60 mM 0.0647 mL 0.3234 mL 0.6467 mL 1.6168 mL
    80 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2126 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AR780306-38-3AR 7AR-7RAR/RXRRetinoic acid receptorsRetinoid X receptorsretinoicacidreceptorCMAmacroautophagyInhibitorinhibitorinhibit

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    目录号：
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