CELSR2 - cadherin EGF LAG seven-pass G-type receptor 2 Gene

中文名称：钙粘蛋白 EGF LAG 七通 G 型受体 2

种属: Homo sapiens

同用名: EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1

关于 CELSR2

功能概要

由该基因编码的蛋白质是火烈鸟亚科的成员，是钙粘蛋白超科的一部分。火烈鸟亚家族由非经典型钙粘蛋白组成；不与连环蛋白相互作用的亚群。火烈鸟钙粘蛋白位于质膜上，在其胞外域中具有九个钙粘蛋白结构域、七个表皮生长因子样重复序列和两个层粘连蛋白 A G 型重复序列。它们还具有七个跨膜结构域，这是该亚科独有的特征。据推测，这些蛋白质是参与接触介导通讯的受体，其中钙粘蛋白结构域充当嗜同性结合区，EGF 样结构域参与细胞粘附和受体-配体相互作用。该特定成员的具体功能尚未确定。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo Cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]