APOBEC3A - apolipoprotein B mRNA editing enzyme catalytic subunit 3A Gene

中文名称：载脂蛋白 B mRNA 编辑酶催化亚基 3A

种属: Homo sapiens

同用名: A3A; ARP3; PHRBN; bK150C2.1

关于 APOBEC3A

功能概要

该基因是胞苷脱氨酶基因家族的成员。它是在一个簇中发现的七个相关基因或假基因之一，被认为是由 22 号染色体上的基因复制引起的。该簇的成员编码的蛋白质在结构和功能上与 C 到 U RNA 编辑胞苷脱氨酶 APOBEC1 相关。该基因编码的蛋白质缺乏其他家族成员的锌结合活性。该蛋白质通过限制病毒等外源 DNA 的传播而在免疫中发挥作用。外源 DNA 限制的一种机制是外源双链 DNA 胞苷脱氨为尿苷，这会导致 DNA 降解。然而，也被认为涉及其他机制，因为抗病毒作用不依赖于脱氨酶活性。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2012 年 7 月]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of Other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, Other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]