MUC20 - mucin 20, cell surface associated Gene

中文名称：粘蛋白 20，细胞表面相关

种属: Homo sapiens

同用名: MUC-20

关于 MUC20

功能概要

该基因编码粘蛋白家族的一个成员。粘蛋白是由许多上皮组织分泌的高分子量糖蛋白，可形成不溶性粘液屏障。该家族成员的 C 端与 MET 原癌基因的多功能停靠位点相关联，并抑制一些下游 MET 信号级联的激活。该蛋白质具有粘蛋白串联重复结构域，在大多数个体中该结构域在 2 到 6 个拷贝之间变化。已发现该基因编码不同亚型的多个变体。已经确定了一个相关的假基因，它也位于 3 号染色体上。[RefSeq 提供，2014 年 4 月]

This gene encodes a member of the Mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a Mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]