2. Gene
  3. Sema3a - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Gene

Sema3a - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: SemD; SEMA1; Semad; coll-1; Hsema-I

基因 ID: 20346 | 基因类型: protein coding

关于 Sema3a

功能概要

Enables chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of male gonad development; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including dichotomous subdivision of terminal units involved in salivary gland branching; generation of neurons; and negative regulation of epithelial cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A). [provided by Alliance of Genome Resources, Apr 2022]

Sema3a 基因产物(3)

mRNA Protein Name
NM_001243072.1 NP_001230001.1 semaphorin-3A precursor
NM_001243073.1 NP_001230002.1 semaphorin-3A precursor
NM_009152.4 NP_033178.2 semaphorin-3A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemorepellent activity IDA
IDA: 通过直接分析推断
11683995 MGI
enables neuropilin binding IPI
IPI: 通过物理相互作用推断
15239958 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23104057 MGI
enables semaphorin receptor binding IPI
IPI: 通过物理相互作用推断
15239958 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of axon extension IDA
IDA: 通过直接分析推断
12852851 MGI
acts upstream of axon extension IGI
IGI: 通过遗传相互作用推断
12852851 MGI
acts upstream of axon extension involved in axon guidance IDA
IDA: 通过直接分析推断
7748561 MGI
acts upstream of axon extension involved in axon guidance IGI
IGI: 通过遗传相互作用推断
11683995 MGI
involved in axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
22790009 MGI
acts upstream of or within axon guidance IDA
IDA: 通过直接分析推断
12435358 MGI
acts upstream of or within axon guidance IMP
IMP: 通过突变表型推断
15604101 MGI
acts upstream of or within axonal fasciculation IMP
IMP: 通过突变表型推断
17428830 MGI
involved in axonogenesis involved in innervation IMP
IMP: 通过突变表型推断
22790009 MGI
involved in basal dendrite arborization IGI
IGI: 通过遗传相互作用推断
22683681 MGI
involved in branchiomotor neuron axon guidance IMP
IMP: 通过突变表型推断
18804103 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
12372285 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IDA
IDA: 通过直接分析推断
17626059 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IGI
IGI: 通过遗传相互作用推断
17626059 MGI
acts upstream of epithelial cell migration IDA
IDA: 通过直接分析推断
17626059 MGI
involved in facial nerve structural organization IMP
IMP: 通过突变表型推断
18804103 MGI
involved in facioacoustic ganglion development IMP
IMP: 通过突变表型推断
18356247 MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
IMP: 通过突变表型推断
21059704 MGI
involved in maintenance of synapse structure IDA
IDA: 通过直接分析推断
24831527 MGI
involved in maintenance of synapse structure IMP
IMP: 通过突变表型推断
24831527 MGI
involved in motor neuron axon guidance IMP
IMP: 通过突变表型推断
18804103 MGI
acts upstream of or within negative chemotaxis IGI
IGI: 通过遗传相互作用推断
11683995 MGI
acts upstream of or within negative regulation of axon extension IDA
IDA: 通过直接分析推断
12852851 MGI
acts upstream of or within negative regulation of axon extension IGI
IGI: 通过遗传相互作用推断
12852851 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IDA
IDA: 通过直接分析推断
7748561 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IGI
IGI: 通过遗传相互作用推断
11683995 MGI
acts upstream of or within negative regulation of epithelial cell migration IDA
IDA: 通过直接分析推断
17626059 MGI
involved in nerve development IMP
IMP: 通过突变表型推断
22790009 MGI
acts upstream of or within nervous system development IGI
IGI: 通过遗传相互作用推断
12591607 MGI
involved in neural crest cell migration involved in autonomic nervous system development IMP
IMP: 通过突变表型推断
18356247 MGI
involved in neural crest cell migration involved in sympathetic nervous system development IMP
IMP: 通过突变表型推断
19325129 MGI
involved in neuron migration IMP
IMP: 通过突变表型推断
21059704 MGI
involved in positive regulation of male gonad development IMP
IMP: 通过突变表型推断
22790009 MGI
involved in positive regulation of neuron migration IGI
IGI: 通过遗传相互作用推断
21828096 MGI
involved in regulation of axon extension involved in axon guidance IDA
IDA: 通过直接分析推断
15155748 MGI
acts upstream of or within regulation of heart rate IMP
IMP: 通过突变表型推断
17417650 MGI
acts upstream of or within semaphorin-plexin signaling pathway IGI
IGI: 通过遗传相互作用推断
12591607 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: 通过突变表型推断
18804103 MGI
involved in sympathetic ganglion development IMP
IMP: 通过突变表型推断
22790009 MGI
involved in sympathetic neuron projection extension IMP
IMP: 通过突变表型推断
22790009 MGI
involved in sympathetic neuron projection guidance IMP
IMP: 通过突变表型推断
22790009 MGI
involved in synaptic target recognition IDA
IDA: 通过直接分析推断
22179111 MGI
involved in synaptic target recognition IMP
IMP: 通过突变表型推断
22179111 MGI
involved in trigeminal ganglion development IMP
IMP: 通过突变表型推断
18356247 MGI
involved in trigeminal nerve structural organization IMP
IMP: 通过突变表型推断
18804103 MGI
involved in ventral trunk neural crest cell migration IMP
IMP: 通过突变表型推断
19386662 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
24831527 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: 通过突变表型推断
24831527 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22179111 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22179111 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

semaphorin-3A

collapsin-1

sema D

sema III

semaphorin III

semaphorin-D

Sema3a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Sema3a O08665 Nrp1 Mus musculus P97333
SPR
23104057
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Sema3a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74566 Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, Fc) O08665 (K26-F546) ≥95%
HY-P78350 Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His) O08665 (Y21-V772) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103511 TCS1105 99.66% 否
HY-RS12650 SEMA3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sema3a NCBI NCBI:10371
Rattus norvegicus Sema3a NCBI NCBI:29751
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