1. Gene
  2. Slc16a1 - solute carrier family 16 (monocarboxylic acid transporters), member 1 Gene

Slc16a1 - solute carrier family 16 (monocarboxylic acid transporters), member 1 Gene

中文名称:溶质载体家族 16 (单羧酸转运蛋白) ,成员 1

种属: Mus musculus

同用名: Mct1

基因 ID: 20501 | 基因类型: protein coding

关于 Slc16a1

Chromosome 3: 104,545,984-104,565,778 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 339 orthologues and 13 paralogues. Ubiquitous expression in colon adult (RPKM 55.3), placenta adult (RPKM 47.) and 27 other tissues.

功能概要

该基因编码的蛋白可启动乳酸跨膜转运蛋白活性。涉及多个过程,包括对营养的行为反应;质膜乳酸转运;和胰岛素分泌的调节。位于质膜和突触中。以多种结构表达,包括消化系统;脑;泌尿生殖系统;外皮系统;和感觉器官。该基因的人类直系同源物与家族性高胰岛素血症性低血糖症 7 相关。与人类 SLC16A1(溶质载体家族 16 成员 1)直系同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables lactate transmembrane transporter activity. Involved in several processes, including behavioral response to nutrient; plasma membrane lactate transport; and regulation of Insulin secretion. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a1 基因产物(1)

mRNA Protein Name
NM_009196.4 NP_033222.1 monocarboxylate transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lactate transmembrane transporter activity IMP
IMP: 通过突变表型推断
29026134 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21792931 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to nutrient IMP
IMP: 通过突变表型推断
24367518 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
22522610 MGI
involved in lipid metabolic process IMP
IMP: 通过突变表型推断
24367518 MGI
involved in plasma membrane lactate transport IMP
IMP: 通过突变表型推断
29026134 MGI
involved in pyruvate catabolic process IMP
IMP: 通过突变表型推断
29026134 MGI
involved in regulation of insulin secretion IMP
IMP: 通过突变表型推断
22522610 MGI
involved in response to food IMP
IMP: 通过突变表型推断
24367518 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
15037112 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
21792931 MGI
is active in synapse EXP
EXP: 通过实验结果推断
15572359 MGI
is active in synapse IDA
IDA: 通过直接分析推断
15572359 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Slc16a1 蛋白结构

2A0113

2A0113: TIGR00892 (0 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

monocarboxylate transporter 1

solute carrier family 16 member 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc16a1 NCBI NCBI:6566