Aurka - aurora kinase A Gene

中文名称：极光激酶 A

种属: Mus musculus

同用名: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A

关于 Aurka

功能概要

该基因编码的蛋白可启动组蛋白丝氨酸激酶活性和泛素蛋白连接酶结合活性。作用于多个过程的上游或内部，包括微管细胞骨架组织；卵母细胞成熟的正调节；和蛋白质定位到中心体。位于轴突丘；微管细胞骨架；和核。以多种结构表达，包括消化系统；骨;脑;眼睛;和泌尿生殖系统。该基因的人类直系同源物与结直肠癌有关；卵巢癌;和子宫癌。与人类 AURKA（极光激酶 A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone serine kinase activity and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including microtubule Cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]