2. Gene
  3. Aurka - aurora kinase A Gene

Aurka - aurora kinase A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：极光激酶 A

种属: Mus musculus

同用名: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A

基因 ID: 20878 | 基因类型: protein coding

关于 Aurka

Chromosome 2: 172,198,110-172,212,455 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 34 phenotypes. Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues.

功能概要

该基因编码的蛋白可启动组蛋白丝氨酸激酶活性和泛素蛋白连接酶结合活性。作用于多个过程的上游或内部，包括微管细胞骨架组织；卵母细胞成熟的正调节；和蛋白质定位到中心体。位于轴突丘；微管细胞骨架；和核。以多种结构表达，包括消化系统；骨;脑;眼睛;和泌尿生殖系统。该基因的人类直系同源物与结直肠癌有关；卵巢癌;和子宫癌。与人类 AURKA（极光激酶 A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone serine kinase activity and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including microtubule Cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]

Aurka 基因产物(2)

mRNA Protein Name
NM_011497.4 NP_035627.1 aurora kinase A isoform a
NM_001291185.1 NP_001278114.1 aurora kinase A isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3S10 kinase activity IMP
IMP: 通过突变表型推断
21274965 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15793587 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
9245792 MGI
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
15793587 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior axis specification IMP
IMP: 通过突变表型推断
22939930 MGI
acts upstream of apoptotic process IMP
IMP: 通过突变表型推断
22939930 MGI
acts upstream of or within centrosome cycle IGI
IGI: 通过遗传相互作用推断
17060449 MGI
acts upstream of or within centrosome localization IMP
IMP: 通过突变表型推断
22832491 MGI
acts upstream of or within meiotic cell cycle IMP
IMP: 通过突变表型推断
21274965 MGI
acts upstream of or within meiotic spindle organization IMP
IMP: 通过突变表型推断
14695913 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
19668197 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: 通过突变表型推断
15793587 MGI
acts upstream of or within mitotic centrosome separation IGI
IGI: 通过遗传相互作用推断
17060449 MGI
acts upstream of or within mitotic centrosome separation IMP
IMP: 通过突变表型推断
19075002 MGI
acts upstream of or within mitotic spindle organization IMP
IMP: 通过突变表型推断
18345035 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22939930 MGI
acts upstream of or within negative regulation of spindle checkpoint IMP
IMP: 通过突变表型推断
19075002 MGI
acts upstream of or within neuron projection extension IGI
IGI: 通过遗传相互作用推断
19668197 MGI
acts upstream of or within positive regulation of oocyte maturation IMP
IMP: 通过突变表型推断
14695913 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
17060449 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
17060449 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: 通过突变表型推断
17060449 MGI
acts upstream of or within protein phosphorylation IGI
IGI: 通过遗传相互作用推断
17060449 MGI
acts upstream of or within spindle assembly involved in female meiosis I IMP
IMP: 通过突变表型推断
21274965 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon hillock IDA
IDA: 通过直接分析推断
19668197 MGI
located in centrosome IDA
IDA: 通过直接分析推断
9245792 MGI
located in germinal vesicle IDA
IDA: 通过直接分析推断
14695913 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11980711 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
11980711 MGI
located in meiotic spindle IDA
IDA: 通过直接分析推断
14695913 MGI
located in microtubule organizing center IDA
IDA: 通过直接分析推断
27753540 MGI
located in microtubule organizing center IGI
IGI: 通过遗传相互作用推断
19668197 MGI
located in mitotic spindle IDA
IDA: 通过直接分析推断
9245792 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
11980711 MGI
is active in postsynaptic density IEP
IEP: 通过表达模式推断
11980711 MGI
located in pronucleus IDA
IDA: 通过直接分析推断
14695913 MGI
located in spindle pole IDA
IDA: 通过直接分析推断
27753540 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Aurka 蛋白结构

PKc_like

PKc_like: cl21453 (117 - 373)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
蛋白主名 其他名称

aurora kinase A

aurora 2

aurora A

aurora family kinase 1

aurora-related kinase 1

aurora/IPL1-related kinase 1

ipl1- and aurora-related kinase 1

serine/threonine kinase 6

serine/threonine-protein kinase 15

serine/threonine-protein kinase 6

serine/threonine-protein kinase Ayk1

serine/threonine-protein kinase aurora-A

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103645 GW779439X 99.85% 否
HY-112273A CD532 hydrochloride Inhibitor 99.62% 否
HY-157396 JAB-2485 98.11% 否
HY-112273 CD532 Inhibitor 98.78% 否
HY-137344A dAURK-4 hydrochloride Inhibitor 99.44% 否
HY-125956 Aurkin A Inhibitor ≥98.0% 否
HY-100865 BPR1K871 Inhibitor 99.12% 否
HY-148065 FMF-06-098-1 / 否
HY-158038 AurkA allosteric-IN-1 Inhibitor / 否
HY-137344 dAURK-4 Inhibitor / 否
HY-147703 Aurora kinase inhibitor-9 Inhibitor / 否
HY-155464 VEGFR-2/AURKA-IN-1 Chemical / 否
HY-161407 AURKA-IN-1 Inhibitor / 否
HY-162469 6K465 Inhibitor / 否
HY-162837 AURKA against 1 Inhibitor / 否
HY-168540 PROTAC MPS1 degrader 1 Degrader / 否
HY-168543 PROTAC MPS1 degrader 2 Degrader / 否
HY-RS01266 AURKA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01267 Aurka Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01268 Aurka Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125090 PHA-680626 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aurka NCBI NCBI:6790
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