2. Gene
  3. Tgfbr3 - transforming growth factor, beta receptor III Gene

Tgfbr3 - transforming growth factor, beta receptor III Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：转化生长因子， β 受体 II I

种属: Mus musculus

同用名: TBRIII; 1110036H20Rik

基因 ID: 21814 | 基因类型: protein coding

关于 Tgfbr3

Chromosome 5: 107,254,436-107,437,495 reverse strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 52 phenotypes. Broad expression in adrenal adult (RPKM 38.6), bladder adult (RPKM 2.1) and 2 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 PDZ 域绑定活动；转化生长因子β结合活性；和转化生长因子 β 激活受体活性。参与几个过程，包括确定性红细胞分化；心脏发育；和跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路。作用于多个过程的上游或内部，包括对 NF-kappaB 转录因子活性的正向调节；跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路的正调控；和血管生成。位于细胞表面和内质网。以多种结构表达，包括大脑；早孕;心;下颌;和卵巢。与人 TGFBR3（转化生长因子 β 受体 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; heart; lower jaw; and ovary. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr3 基因产物(1)

mRNA Protein Name
NM_011578.4 NP_035708.2 transforming growth factor beta receptor type 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
11546783 MGI
enables SMAD binding IMP
IMP: 通过突变表型推断
17295310 MGI
enables glycosaminoglycan binding IDA
IDA: 通过直接分析推断
12773577 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12773577 MGI
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
17295310 MGI
enables transforming growth factor beta receptor activity IDA
IDA: 通过直接分析推断
9659379 MGI
enables transforming growth factor beta receptor activity IMP
IMP: 通过突变表型推断
17823118 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of BMP signaling pathway IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of apoptotic process involved in morphogenesis IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of or within blastocyst development IDA
IDA: 通过直接分析推断
9921650 MGI
acts upstream of or within blood vessel development IMP
IMP: 通过突变表型推断
17704211 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: 通过突变表型推断
25382630 MGI
involved in cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
12773577 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
25382630 MGI
involved in collagen metabolic process IGI
IGI: 通过遗传相互作用推断
22960625 MGI
involved in definitive erythrocyte differentiation IMP
IMP: 通过突变表型推断
12773577 MGI
involved in definitive hemopoiesis IMP
IMP: 通过突变表型推断
12773577 MGI
involved in epicardium-derived cardiac fibroblast cell development IMP
IMP: 通过突变表型推断
17704211 MGI
involved in heart trabecula formation IMP
IMP: 通过突变表型推断
12773577 MGI
involved in heart trabecula morphogenesis IMP
IMP: 通过突变表型推断
12773577 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
17704211 MGI
involved in liver development IMP
IMP: 通过突变表型推断
12773577 MGI
involved in muscular septum morphogenesis IMP
IMP: 通过突变表型推断
12773577 MGI
acts upstream of or within negative regulation of apoptotic process involved in morphogenesis IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of or within negative regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
17823118 MGI
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
17295310 MGI
acts upstream of or within negative regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
17823118 MGI
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
22960625 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
25382630 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
17704211 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
17823118 MGI
involved in positive regulation of SMAD protein signal transduction IMP
IMP: 通过突变表型推断
17295310 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
12773577 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
25382630 MGI
NOT involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
12773577 MGI
NOT involved in regulation of JNK cascade IMP
IMP: 通过突变表型推断
12773577 MGI
acts upstream of or within roof of mouth development IMP
IMP: 通过突变表型推断
25382630 MGI
involved in secondary palate development IMP
IMP: 通过突变表型推断
17295310 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11546783 MGI
involved in transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12773577 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
25382630 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
25382630 MGI
involved in vasculogenesis involved in coronary vascular morphogenesis IMP
IMP: 通过突变表型推断
17704211 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
12773577 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: 通过突变表型推断
12773577 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
17704211 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
11546783 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
9921650 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
9921650 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tgfbr3 蛋白结构

ZP

ZP: smart00241 (453 - 722)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 850 a.a.
蛋白主名 其他名称

transforming growth factor beta receptor type 3

TGF-beta receptor type 3

TGF-beta receptor type III

TGFR-3

betaglycan

重组 Tgfbr3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72452 TGFBR3/TGF-beta RIII Protein, Mouse (763a.a, HEK293, His) A0A0R4J097 (G23-T785) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14450 TGFBR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14451 Tgfbr3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14452 Tgfbr3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14453 TGFBR3L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgfbr3 NCBI NCBI:7049
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