2. Gene
  3. Timp2 - tissue inhibitor of metalloproteinase 2 Gene

Timp2 - tissue inhibitor of metalloproteinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Timp-2; D11Bwg1104e

基因 ID: 21858 | 基因类型: protein coding

关于 Timp2

功能概要

Enables Enzyme activator activity; Integrin binding activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of MAPK cascade; and regulation of neuron differentiation. Located in basement membrane and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skeletal system. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Apr 2022]

Timp2 基因产物(1)

mRNA Protein Name
NM_011594.3 NP_035724.2 metalloproteinase inhibitor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme activator activity IMP
IMP: 通过突变表型推断
10827175 MGI
enables integrin binding IDA
IDA: 通过直接分析推断
15901773 MGI
enables metalloendopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
10827176 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15901773 MGI
acts upstream of or within regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15901773 MGI
acts upstream of or within regulation of neuron differentiation IDA
IDA: 通过直接分析推断
15901773 MGI
acts upstream of or within regulation of neuron differentiation IMP
IMP: 通过突变表型推断
15901773 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
12950084 MGI
located in cell surface IDA
IDA: 通过直接分析推断
15901773 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

metalloproteinase inhibitor 2

tissue inhibitor of metalloproteinases 2

重组 Timp2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71137 TIMP-2 Protein, Mouse (HEK293, His) P25785 (C27-P220) ≥95%
HY-P71137A TIMP-2 Protein, Mouse (HEK293, C-His) P25785 (C27-P220) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14539 TIMP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Timp2 NCBI NCBI:7077
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