1. Gene
  2. ARMC3 - armadillo repeat containing 3 Gene

ARMC3 - armadillo repeat containing 3 Gene

中文名称:含犰狳重复 3

种属: Homo sapiens

同用名: CT81; KU-CT-1

基因 ID: 219681 | 基因类型: protein coding

关于 ARMC3

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:22,928,053-23,038,523 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 12.8).

功能概要

犰狳/β-连环蛋白 (CTNNB1;MIM 116806) 样 (ARM) 结构域是不完整的 45 氨基酸重复序列,参与蛋白质-蛋白质相互作用。包含 ARM 结构域的蛋白质,例如 ARMC3,在信号转导、发育、细胞粘附和移动以及肿瘤起始和转移中起作用 (Li 等人,2006 [PubMed 16915934]) 。[OMIM 提供,2008 年 3 月]

Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]

ARMC3 基因产物(4)

mRNA Protein Name
NM_001282745.2 NP_001269674.1 armadillo repeat-containing protein 3 isoform 2
NM_001282746.2 NP_001269675.1 armadillo repeat-containing protein 3 isoform 3
NM_001282747.2 NP_001269676.1 armadillo repeat-containing protein 3 isoform 4
NM_173081.5 NP_775104.2 armadillo repeat-containing protein 3 isoform 1

ARMC3 蛋白结构

Arm

Arm: Armadillo/beta-catenin-like repeat (57 - 89)

HEAT_2

HEAT_2: HEAT repeats (152 - 245)

HEAT_2

HEAT_2: HEAT repeats (276 - 381)

Arm

Arm: Armadillo/beta-catenin-like repeat (387 - 426)

Arm

Arm: Armadillo/beta-catenin-like repeat (471 - 503)

EDR1

EDR1: Ethylene-responsive protein kinase Le-CTR1 (737 - 859)

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  • 872 a.a.
蛋白主名 其他名称

armadillo repeat-containing protein 3

beta-catenin-like protein

关联疾病

疾病名称 别名
Macular Degeneration, Age-Related, 4

Age Related Macular Degeneration 4

ARMD4

Macular Degeneration, Age-Related, Type 4

Currarino Syndrome

Currarino Triad

Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation

CURRAS

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARMC3 MGD MGI:1918132
Bos taurus ARMC3 VGNC VGNC:26157
Rattus norvegicus ARMC3 RGD RGD:2319961
Canis familiaris ARMC3 VGNC VGNC:38125
Macaca mulatta ARMC3 VGNC VGNC:69932
Felis catus ARMC3 VGNC VGNC:59932
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