2. Gene
  3. FAU - FAU ubiquitin like and ribosomal protein S30 fusion Gene

FAU - FAU ubiquitin like and ribosomal protein S30 fusion Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FAU 泛素样和核糖体蛋白 S30 融合

种属: Homo sapiens

同用名: S30; FAU1; Fub1; Fubi; asr1; RPS30; MNSFbeta

基因 ID: 2197 | 基因类型: protein coding

关于 FAU

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,120,630-65,122,134 (from NCBI)

This gene has 9 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in ovary (RPKM 446.2), bone marrow (RPKM 364.4) and 25 other tissues.

功能概要

该基因是 Finkel-Biskis-Reilly 鼠肉瘤病毒 (FBR-MuSV) 中 fox 序列的细胞同系物。它编码一种融合蛋白，由 N 端的泛素样蛋白 fubi 和 C 端的核糖体蛋白 S30 组成。已经提出融合蛋白经过翻译后加工以产生游离的 fubi 和游离的核糖体蛋白 S30。 Fubi 是泛素家族的成员，核糖体蛋白 S30 属于核糖体蛋白 S30E 家族。虽然 fubi 的功能目前未知，但核糖体蛋白 S30 是细胞质核糖体 40S 亚基的组成部分，具有抗菌活性。来自该基因的假基因存在于基因组中。与核糖体蛋白 S30 类似，核糖体蛋白 S27a 和 L40 被合成为与泛素的融合蛋白。[RefSeq 提供，2014 年 11 月]

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the Ubiquitin-Like Protein FUBI at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]

FAU 基因产物(1)

mRNA Protein Name
NM_001997.5 NP_001988.1 FAU ubiquitin-like and ribosomal protein S30 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial humoral response IDA
IDA: 通过直接分析推断
12860195 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12860195 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
12860195 GOA
involved in innate immune response in mucosa IDA
IDA: 通过直接分析推断
12860195 GOA
involved in ribosomal small subunit assembly IDA
IDA: 通过直接分析推断
34318747 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
12860195 GOA
located in nucleus IDA
IDA: 通过直接分析推断
34318747 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAU 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (9 - 70)

Ribosomal_S30

Ribosomal_S30: Ribosomal protein S30 (75 - 133)

  • 0
  • 100
  • 133 a.a.
蛋白主名 其他名称

FAU ubiquitin-like and ribosomal protein S30

40S ribosomal protein S30

重组 FAU 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71681 FAU Protein, Human (GST) P62861/NM_001997 (M1-S133) ≥95%

关联疾病

疾病名称 别名
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma
Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04765 FAU Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FAU VGNC VGNC:101085
Canis familiaris FAU VGNC VGNC:51871
Mus musculus FAU MGD MGI:102547
Rattus norvegicus FAU RGD RGD:61938
Others FAU NCBI
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