1. Gene
  2. RTKN2 - rhotekin 2 Gene

RTKN2 - rhotekin 2 Gene

中文名称:罗特金 2

种属: Homo sapiens

同用名: PLEKHK1; bA531F24.1

基因 ID: 219790 | 基因类型: protein coding

关于 RTKN2

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,183,900-62,268,844 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 2 paralogues. Biased expression in lung (RPKM 32.1) and testis (RPKM 2.2).

功能概要

参与内在凋亡信号通路的负调控; NF-kappaB 转录因子活性的正调控;和 NIK/NF-kappaB 信号的正调控。位于细胞质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of NIK/NF-kappaB signaling. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RTKN2 基因产物(2)

mRNA Protein Name
NM_001282941.2 NP_001269870.1 rhotekin-2 isoform 2
NM_145307.4 NP_660350.2 rhotekin-2 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15504364 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15504364 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RTKN2 蛋白结构

Anillin

Anillin: Cell division protein anillin (97 - 247)

PH

PH: PH domain (290 - 388)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 609 a.a.
蛋白主名 其他名称

rhotekin-2

PH domain-containing family K member 1

直系同源

种属 基因名 来源 基因 ID
Felis catus RTKN2 VGNC VGNC:64808
Canis familiaris RTKN2 VGNC VGNC:45790
Bos taurus RTKN2 VGNC VGNC:34198
Macaca mulatta RTKN2 VGNC VGNC:77055
Mus musculus RTKN2 MGD MGI:2158417
Rattus norvegicus RTKN2 RGD RGD:1304834