2. Gene
  3. FCAR - Fc alpha receptor Gene

FCAR - Fc alpha receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Fcα受体

种属: Homo sapiens

同用名: CD89; FcalphaR; FcalphaRI; CTB-61M7.2

基因 ID: 2204 | 基因类型: protein coding

关于 FCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,874,235-54,891,420 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 69 orthologues and 25 paralogues. Restricted expression toward bone marrow (RPKM 95.4).

功能概要

该基因是免疫球蛋白基因超家族的成员，编码 IgA Fc 区的受体。该受体是一种跨膜糖蛋白，存在于中性粒细胞、单核细胞、巨噬细胞和嗜酸性粒细胞等髓系细胞表面，介导对病原体的免疫反应。它与 IgA 调理靶标相互作用并触发多种免疫防御过程，包括吞噬作用、抗体依赖性细胞介导的细胞毒性和刺激炎症介质的释放。已针对该基因描述了编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

FCAR 基因产物(8)

mRNA Protein Name
NM_002000.4 NP_001991.1 immunoglobulin alpha Fc receptor isoform a precursor
NM_133269.4 NP_579803.1 immunoglobulin alpha Fc receptor isoform b precursor
NM_133271.4 NP_579805.1 immunoglobulin alpha Fc receptor isoform c precursor
NM_133272.4 NP_579806.1 immunoglobulin alpha Fc receptor isoform d
NM_133273.4 NP_579807.1 immunoglobulin alpha Fc receptor isoform e
NM_133274.4 NP_579808.1 immunoglobulin alpha Fc receptor isoform f
NM_133277.4 NP_579811.1 immunoglobulin alpha Fc receptor isoform g
NM_133278.4 NP_579812.1 immunoglobulin alpha Fc receptor isoform h

FCAR 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (29 - 117)

Ig_2

Ig_2: Immunoglobulin domain (126 - 215)

  • 0
  • 100
  • 200
  • 287 a.a.
蛋白主名 其他名称

immunoglobulin alpha Fc receptor

Fc fragment of IgA receptor

重组 FCAR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72657 FCAR/CD89 Protein, Human (HEK293, His) P24071-1 (Q22-N227) ≥95%

FCAR 抗体

目录号 产品名 应用 反应物种
HY-P82215 CD89 Antibody (YA1960) WB, IHC-P, ICC/IF, IP, FC Human

关联疾病

疾病名称 别名
Iga Glomerulonephritis

Iga Nephropathy

Glomerulonephritis, Iga

Berger'S Iga Or Igg Nephropathy

Focal Glomerulonephritis

Primary Iga Nephropathy

Segmental Glomerulonephritis

Berger Disease

Berger'S Disease

Igan

Nephritis, Iga Type

Nephropathy Iga

Glomerulonephritis Focal

Iga Nephropathy, Susceptibility To

Primary Immunoglobulin A Nephropathy
Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis

Portal Cirrhosis

Alcoholic Cirrhosis Of Liver

Liver Cirrhosis, Alcoholic

Laennec'S Cirrhosis

Laennec'S Cirrhosis, Alcoholic

Alcohol Cirrhosis

Alcoholic Laennec Cirrhosis

Alcoholic Cirrhosis Nos

Etoh Cirrhosis

Alcohol Hepatic Cirrhosis

Alcohol Liver Cirrhosis

Laennec Cirrhosis
Glomerulonephritis

Bright'S Disease
Erythema Elevatum Diutinum
Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis

Hypersensitivity Angiitis

Cutaneous Leukocytoclastic Vasculitis

Leukocytoclastic Angiitis

Vasculitis, Leukocytoclastic, Cutaneous

Leukocytoclastic Vasculitis

Cutaneous Leukocytoclastic Angiitis

Cutaneous Hypersensitivity Vasculitis

Vasculitis Hypersensitivity

Drug Induced Cutaneous Vasculitis

Allergic Vasculitis
Inflammatory Bowel Disease 10

Inflammatory Bowel Disease 10

IBD10

Inflammatory Bowel Disease 10, Susceptibility To

Bowel Disease, Inflammatory, Type 10
Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases

Immune Complex Disease

Type Iii Hypersensitivity Reaction Disease
Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura

Iga Vasculitis

Allergic Purpura

Anaphylactoid Purpura

Rheumatoid Purpura

Immunoglobulin A Vasculitis

Vascular Purpura

Purpura Rheumatica

Henoch-Schönlein Purpura

Autoimmune Purpura

Henoch-Schnlein Purpura

Henoch-Sch@Nlein Purpura

Henoch-Scholein Purpura

Purpura, Autoimmune

Henoch Schonlein Purpura

Immunoglobulin-A Vasculitis

Purpura, Schonlein-Henoch

Purpura, Schönlein-Henoch

Hsp -

Schönlein-Henoch Purpura
Immunoglobulin Alpha Deficiency

Iga Deficiency

Gamma-A-Globulin Deficiency

Immunoglobulin A Deficiency
Spondyloarthropathy 1

Ankylosing Spondylitis

Spondyloarthropathy, Susceptibility To, 1

SPDA1

Marie-Strumpell Spondylitis

Bechterew Syndrome

Spa

Spondylarthritis Ankylopoietica

Reiter Syndrome

Ankylosing Spondylitis, Susceptibility To

Bekhterev Syndrome

Bekhterev'S Disease

Marie-Strumpell Disease

Axial Spondylarthritis

Bechterew Disease

Marie-Struempell Disease

Spondylitis Ankylopoietica

Spondyloarthritis

Spondyloarthritis Ankylopoietica

Spas

Ankylosing Spondylarthritis

Psoriatic Arthritis

Reactive Arthritis

Rheumatoid Spondylitis

Spondylitis Ankylosans

Spondylitis Ankylosing

Spondylitis, Ankylosing

Spondylarthropathies

Arthritis, Psoriatic

Arthritis, Reactive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04821 FCAR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FCAR VGNC VGNC:72627
Rattus norvegicus FCAR RGD RGD:1303082
Bos taurus FCAR VGNC VGNC:28929
Others FCAR NCBI
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