1. Gene
  2. OPN5 - opsin 5 Gene

OPN5 - opsin 5 Gene

中文名称:视蛋白 5

种属: Homo sapiens

同用名: PGR12; GPR136; GRP136; TMEM13

基因 ID: 221391 | 基因类型: protein coding

关于 OPN5

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:47,782,032-47,826,381 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 9 paralogues. Restricted expression toward testis (RPKM 1.6).

功能概要

视蛋白是鸟嘌呤核苷酸结合蛋白 (G 蛋白) 偶联受体超家族的成员。这种视蛋白基因在眼睛、大脑、睾丸和脊髓中表达。该基因属于哺乳动物视蛋白基因的七外显子亚家族,包括视蛋白 (RRH) 和视网膜 G 蛋白偶联受体 (RGR) 。与这些其他七外显子视蛋白基因一样,该家族成员可能编码具有光异构酶活性的蛋白质。可变剪接导致多个转录本变体。[RefSeq 提供,2010 年 6 月]

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these Other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

OPN5 基因产物(1)

mRNA Protein Name
NM_181744.4 NP_859528.1 opsin-5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 11-cis retinal binding IMP
IMP: 通过突变表型推断
22043319 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV-A IDA
IDA: 通过直接分析推断
31380578 GOA
involved in phototransduction, UV IMP
IMP: 通过突变表型推断
22043319 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
30168605 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
31380578 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OPN5 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 306)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

opsin-5

G-protein coupled receptor 136

关联疾病

疾病名称 别名
Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OPN5 VGNC VGNC:75439
Felis catus OPN5 VGNC VGNC:63969
Mus musculus OPN5 MGD MGI:2662912
Bos taurus OPN5 VGNC VGNC:32438
Canis familiaris OPN5 VGNC VGNC:44131
Rattus norvegicus OPN5 RGD RGD:727869