2. Gene
  3. Tnfrsf4 - tumor necrosis factor receptor superfamily, member 4 Gene

Tnfrsf4 - tumor necrosis factor receptor superfamily, member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L

基因 ID: 22163 | 基因类型: protein coding

关于 Tnfrsf4

功能概要

Enables tumor necrosis factor-activated receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF Receptor Superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf4 基因产物(1)

mRNA Protein Name
NM_011659.2 NP_035789.1 tumor necrosis factor receptor superfamily member 4 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
7749983 MGI
enables tumor necrosis factor receptor activity IPI
IPI: 通过物理相互作用推断
14635034 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular defense response IMP
IMP: 通过突变表型推断
10586044 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
14730361 MGI
acts upstream of or within inflammatory response IPI
IPI: 通过物理相互作用推断
14635034 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7749983 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7749983 MGI
involved in negative regulation of activation-induced cell death of T cells IMP
IMP: 通过突变表型推断
11567634 MGI
acts upstream of or within negative regulation of cytokine production IPI
IPI: 通过物理相互作用推断
14635034 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11567634 MGI
involved in positive regulation of B cell proliferation IMP
IMP: 通过突变表型推断
7749983 MGI
involved in positive regulation of immunoglobulin production IDA
IDA: 通过直接分析推断
7749983 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
14730361 MGI
acts upstream of or within regulation of protein kinase activity IMP
IMP: 通过突变表型推断
14730361 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
16301745 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10586044 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 4

OX40 antigen

OX40L receptor

tax-transcriptionally activated glycoprotein 1

Tnfrsf4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tnfrsf4 P47741 Rps27a Mus musculus P62991
Anti Tag CoIP
21282629
种属内
Tnfrsf4 P47741 Traf2 Mus musculus P39429
Anti Tag CoIP
21282629
种属内
Tnfrsf4 P47741 Traf2 Mus musculus P39429
Y2H
9418902
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Tnfrsf4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72499 OX40/TNFRSF4 Protein, Mouse (HEK293, His) P47741 (V20-P211) ≥95%
HY-P78190 OX40/TNFRSF4 Protein, Mouse (Biotinylated, HEK293, His-Avi) P47741 (V20-P211) ≥95%
HY-P78334 OX40/TNFRSF4 Protein, Mouse (HEK293, His-Avi) P47741 (V20-P211) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14814 TNFRSF4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfrsf4 NCBI NCBI:7293
Macaca fascicularis Tnfrsf4 NCBI NCBI:102145978
Macaca mulatta Tnfrsf4 NCBI NCBI:699674
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