1. Gene
  2. GPC2 - glypican 2 Gene

GPC2 - glypican 2 Gene

中文名称:磷脂酰肌醇 2

种属: Homo sapiens

基因 ID: 221914 | 基因类型: protein coding

关于 GPC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,169,606-100,177,381 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 5 paralogues. Biased expression in testis (RPKM 5.5), skin (RPKM 2.9) and 7 other tissues.

功能概要

预计参与多个过程,包括神经元投射发育的正调节;调节蛋白质在膜上的定位;和平滑的信号通路。位于内质网。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

GPC2 基因产物(1)

mRNA Protein Name
NM_152742.3 NP_689955.1 glypican-2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29162697 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPC2 蛋白结构

Glypican

Glypican: Glypican (10 - 551)

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  • 500
  • 579 a.a.
蛋白主名 其他名称

glypican-2

cerebroglycan proteoglycan

关联疾病

疾病名称 别名
Keipert Syndrome

Nasodigitoacoustic Syndrome

KPTS

Nasodigitoacoustic Syndrome, Formerly

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Central Corneal Ulcer
Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1

Simpson-Golabi-Behmel Syndrome

SGBS1

Golabi-Rosen Syndrome

Simpson Dysmorphia Syndrome

Sgbs

Bulldog Syndrome

Dgsx

Sdys

Dysplasia Gigantism Syndrome, X-Linked

X-Linked Dysplasia Gigantism Syndrome

Dgsx Golabi-Rosen Syndrome

Sara Angers Syndrome

Sgb Syndrome

Mental Retardation-Overgrowth Syndrome

Simpson Dysplasia Syndrome

Simpson Syndrome

Simpson-Golabi-Behmel Syndrome 1

Dysplasia Gigantism Syndrome X-Linked

Hereditary Multiple Exostoses

Multiple Congenital Exostosis

Hereditary Multiple Exostoses 1

Hereditary Multiple Exostoses 2

Hereditary Multiple Exostoses 3

Multiple Exostosis Syndromes

Multiple Ostechondromas

Osteochondromatosis Syndrome

Exostoses Multiple Hereditary

Exostoses, Multiple Hereditary

Saul-Wilson Syndrome

Microcephalic Osteodysplastic Dysplasia

Microcephalic Osteodysplastic Dysplasia, Saul-Wilson Type

SWILS

Microcephalic Osteodysplastic Dysplasia Saul Wilson Type

Exostosis

Osteophyte

Exostoses

Orbital Exostosis

Exostosis Of Orbit

Bone Spur

Bony Outgrowth

Swimmer'S Exostosis

Osteophytes

External Exotoses

Cartilaginous Exostosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GPC2 VGNC VGNC:41372
Bos taurus GPC2 VGNC VGNC:29524
Macaca mulatta GPC2 VGNC VGNC:108411
Felis catus GPC2 VGNC VGNC:67404
Rattus norvegicus GPC2 RGD RGD:621363
Mus musculus GPC2 MGD MGI:1919201
Others GPC2 NCBI