1. Gene
  2. MMD2 - monocyte to macrophage differentiation associated 2 Gene

MMD2 - monocyte to macrophage differentiation associated 2 Gene

中文名称:单核细胞向巨噬细胞分化相关 2

种属: Homo sapiens

同用名: PAQR10

基因 ID: 221938 | 基因类型: protein coding

关于 MMD2

功能概要

该基因编码 PAQR (孕激素和 adipoQ 受体) 家族的成员。这个家族的成员在进化上是保守的,与细菌溶血素样蛋白具有显着的序列同一性,并且由一组七个跨膜结构域定义。由该基因编码的蛋白质定位于高尔基体以调节 Ras 信号。可变剪接导致多种转录本变体和蛋白质同种型。[RefSeq 提供,2012 年 6 月]

This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to Bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

MMD2 基因产物(3)

mRNA Protein Name
NM_001100600.2 NP_001094070.1 monocyte to macrophage differentiation factor 2 isoform 1
NM_001270375.2 NP_001257304.1 monocyte to macrophage differentiation factor 2 isoform 3
NM_198403.4 NP_940685.3 monocyte to macrophage differentiation factor 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
21968647 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of Ras protein signal transduction IDA
IDA: 通过直接分析推断
21968647 GOA
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
21968647 GOA
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
21968647 GOA
involved in regulation of protein localization IDA
IDA: 通过直接分析推断
21968647 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
22339580 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22500632 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

monocyte to macrophage differentiation factor 2

monocyte-to-macrophage differentiation-associated protein 2