2. Gene
  3. Vcl - vinculin Gene

Vcl - vinculin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 9430097D22

基因 ID: 22330 | 基因类型: protein coding

关于 Vcl

功能概要

Predicted to enable alpha-catenin binding activity; dystroglycan binding activity; and Enzyme binding activity. Acts upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in several cellular components, including costamere; fascia adherens; and focal adhesion. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]

Vcl 基因产物(1)

mRNA Protein Name
NM_009502.5 NP_033528.3 vinculin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10085297 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axon extension IGI
IGI: 通过遗传相互作用推断
24623780 MGI
acts upstream of or within cell adhesion IDA
IDA: 通过直接分析推断
12473693 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: 通过直接分析推断
12473693 MGI
acts upstream of or within regulation of cell migration IDA
IDA: 通过直接分析推断
12473693 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
21048959 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
14657280 MGI
located in costamere IDA
IDA: 通过直接分析推断
15128702 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
24036928 MGI
located in fascia adherens IDA
IDA: 通过直接分析推断
11732910 MGI
located in focal adhesion IDA
IDA: 通过直接分析推断
12711699 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16481394 MGI
located in podosome IDA
IDA: 通过直接分析推断
17893324 MGI
located in podosome ring IDA
IDA: 通过直接分析推断
27505886 MGI
located in sarcolemma IDA
IDA: 通过直接分析推断
26359501 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

vinculin

metavinculin

重组 Vcl 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73549 Vinculin Protein, Mouse (HEK293, His) Q64727 (M1-Q1066) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15620 VCL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Vcl NCBI NCBI:7414
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