FGG - fibrinogen gamma chain Gene

中文名称：纤维蛋白原γ链

种属: Homo sapiens

基因 ID: 2266 | 基因类型: protein coding

关于 FGG

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:154,604,136-154,612,656 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues, 25 paralogues and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 3614.5).

功能概要

该基因编码的蛋白质是纤维蛋白原的γ成分，纤维蛋白原是一种血源性糖蛋白，由三对不同的多肽链组成。血管损伤后，纤维蛋白原被凝血酶裂解形成纤维蛋白，它是血块中最丰富的成分。此外，纤维蛋白原和纤维蛋白的各种裂解产物调节细胞粘附和扩散，表现出血管收缩和趋化活性，并且是多种细胞类型的有丝分裂原。该基因的突变会导致多种疾病，包括异常纤维蛋白原血症、低纤维蛋白原血症和血栓形成倾向。可变剪接导致编码不同亚型的转录变体。[RefSeq 提供，2015 年 8 月]

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by Thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

FGG 基因产物(2)

mRNA	Protein	Name
NM_000509.6	NP_000500.2	fibrinogen gamma chain isoform gamma-A precursor
NM_021870.3	NP_068656.2	fibrinogen gamma chain isoform gamma-B precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell adhesion molecule binding	IPI IPI: 通过物理相互作用推断	7822297	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10788510	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	7822297	GOA
enables structural molecule activity	IDA IDA: 通过直接分析推断	8910396	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in blood coagulation, fibrin clot formation	IDA IDA: 通过直接分析推断	16846481	GOA
involved in blood coagulation, fibrin clot formation	IMP IMP: 通过突变表型推断	11001902	GOA
involved in cell-matrix adhesion	IDA IDA: 通过直接分析推断	10903502	GOA
involved in fibrinolysis	IDA IDA: 通过直接分析推断	16846481	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: 通过直接分析推断	10903502	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: 通过直接分析推断	10903502	GOA
involved in plasminogen activation	IDA IDA: 通过直接分析推断	16846481	GOA
involved in platelet aggregation	IDA IDA: 通过直接分析推断	6281794	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	10903502	GOA
involved in positive regulation of exocytosis	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: 通过直接分析推断	8100742	GOA
involved in positive regulation of peptide hormone secretion	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of protein secretion	IDA IDA: 通过直接分析推断	19193866	GOA
involved in positive regulation of vasoconstriction	IDA IDA: 通过直接分析推断	15739255	GOA
involved in protein polymerization	IMP IMP: 通过突变表型推断	12706644	GOA
involved in protein secretion	IMP IMP: 通过突变表型推断	18676163	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	8910396	GOA
involved in response to calcium ion	IDA IDA: 通过直接分析推断	6777381	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	6777381	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	6777381	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	6777381	GOA
part of fibrinogen complex	IDA IDA: 通过直接分析推断	6451630	GOA
located in platelet alpha granule	IDA IDA: 通过直接分析推断	6777381	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FGG 蛋白结构

Fib_alpha

Fibrinogen_C

0
100
200
300
400
453 a.a.

蛋白主名

其他名称

fibrinogen gamma chain

fibrinogen, gamma polypeptide

FGG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	FGG	P02679	gapA	Mycoplasma pneumoniae	P75358	Far-WB	21546586
种属间	FGG	P02679	gapA	Mycoplasma pneumoniae	P75358	ELISA	21546586

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FGG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75772	FGG/Fibrinogen gamma chain Protein, Human (P.pastoris)	P02679-1/NP_068656.2 (V169-L453)	≥95%

FGG 抗体

目录号	产品名	应用	反应物种
HY-P82151	Fibrinogen gamma Chain Antibody (YA1896)	WB, FC	Human

关联疾病

疾病名称

别名

Afibrinogenemia, Congenital

Congenital Afibrinogenemia	Afibrinogenemia
Factor I Deficiency	Familial Afibrinogenemia
Hypofibrinogenemia, Congenital	Fibrinogen Deficiency
Afibrinogenemia Congenital	CAFBN
Congenital Hypofibrinogenemia	Hypofibrinogenemia
Complement Factor I Deficiency

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Hypofibrinogenemia, Familial

Familial Hypofibrinogenemia

Fibrinogen Deficiency, Congenital

Congenital Fibrinogen Deficiency

Thrombosis

Thrombosis Of Blood Vessel

Thrombophilia

Hypercoagulability State

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Femoral Vein Thrombophlebitis

Phlebitis And Thrombophlebitis Of Femoral Vein	Thrombophlebitis Of The Femoral Vein
Thrombophlebitis Of Deep Femoral Vein

Alopecia-Mental Retardation Syndrome 1

APMR1	Alopecia-Intellectual Disability Syndrome 1
Amr Syndrome	Alopecia-Intellectual Disability Syndrome
Amr Syndrome 1	Alopecia With Severe Intellectual Deficit
Apmr	Alopecia Intellectual Disbility Syndrome 1
Perniola-Krajewska-Carnevale Syndrome	Alopecia - Intellectual Disability Syndrome
Alopecia With Mental Retardation Syndrome 1	Perniola Krajewska Carnevale Syndrome

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Intermediate Malignant Teratoma

Malignant Teratoma, Intermediate

Intermediate Immature Teratoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04925	FGG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	FGG	VGNC	VGNC:54208
Rattus norvegicus	FGG	RGD	RGD:2613
Mus musculus	FGG	MGD	MGI:95526
Felis catus	FGG	VGNC	VGNC:62261
Macaca mulatta	FGG	VGNC	VGNC:72656
Bos taurus	FGG	VGNC	VGNC:28990
Others	FGG	NCBI

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站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FGG - fibrinogen gamma chain Gene

关于 FGG

功能概要

FGG 基因产物(2)

FGG 蛋白结构

FGG 蛋白互作信息

重组 FGG 蛋白

FGG 抗体

关联疾病

直系同源

热门区域

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FGG - fibrinogen gamma chain Gene

关于 FGG

功能概要

FGG 基因产物(2)

FGG 蛋白结构

FGG 蛋白互作信息

重组 FGG 蛋白

FGG 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z