2. Gene
  3. ITGA11 - integrin subunit alpha 11 Gene

ITGA11 - integrin subunit alpha 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：整合素亚基α11

种属: Homo sapiens

同用名: HsT18964

基因 ID: 22801 | 基因类型: protein coding

关于 ITGA11

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,296,532-68,432,163 (from NCBI)

This gene has 7 transcripts (splice variants), 250 orthologues and 17 paralogues. Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues.

功能概要

该基因编码 alpha 整合素。整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。这种蛋白质包含一个 I 结构域，在肌肉组织中表达，在体外与 β1 整合素二聚化，并且似乎以这种形式结合胶原蛋白。因此，该蛋白质可能参与将肌肉组织附着到细胞外基质。已发现该基因的替代转录剪接变体，但尚未确定其生物学有效性。[RefSeq 提供，2008 年 7 月]

This gene encodes an alpha Integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 Integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]

ITGA11 基因产物(1)

mRNA Protein Name
NM_001004439.2 NP_001004439.1 integrin alpha-11 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IMP
IMP: 通过突变表型推断
11518510 GOA
enables collagen binding involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
24823363 GOA
enables collagen receptor activity IMP
IMP: 通过突变表型推断
11518510 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
11518510 GOA
involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
11518510 GOA
involved in collagen-activated signaling pathway IMP
IMP: 通过突变表型推断
11518510 GOA
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
24823363 GOA
involved in substrate-dependent cell migration IMP
IMP: 通过突变表型推断
11518510 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
11518510 GOA
part of integrin alpha11-beta1 complex IDA
IDA: 通过直接分析推断
24823363 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITGA11 蛋白结构

VWA

VWA: von Willebrand factor type A domain (164 - 344)

FG-GAP

FG-GAP: FG-GAP repeat (480 - 518)

Integrin_alpha2

Integrin_alpha2: Integrin alpha (635 - 1048)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1188 a.a.
蛋白主名 其他名称

integrin alpha-11

关联疾病

疾病名称 别名
Brain Oligodendroglioma

Oligodendroglioma Of Brain
Myasthenic Syndrome, Congenital, 19

Congenital Myasthenic Syndrome 19

CMS19

Myasthenic Syndrome, Congenital, Type 19
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Spinal Muscular Atrophy, Type Iv

SMA4

Spinal Muscular Atrophy, Adult Form

Spinal Muscular Atrophy 4

Spinal Muscular Atrophy-4

Adult Spinal Muscular Atrophy

Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive

Proximal Spinal Muscular Atrophy Type 4

Sma Type 4

Sma Type Iv

Sma-Iv

Sma Iv

Spinal Muscular Atrophy Adult Form

Spinal Muscular Atrophy Proximal Adult Autosomal Recessive

Spinal Muscular Atrophy Type Iv

Atrophy, Muscular, Spinal, Type Iv

Myelopathic Muscular Atrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06947 ITGA11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ITGA11 VGNC VGNC:42122
Macaca mulatta ITGA11 VGNC VGNC:73774
Bos taurus ITGA11 VGNC VGNC:30312
Mus musculus ITGA11 MGD MGI:2442114
Rattus norvegicus ITGA11 RGD RGD:1311711
Felis catus ITGA11 VGNC VGNC:67838
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